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Karyotype analysis of S. cerevisiae chromosome replacement lines - alpha-type cells

ABSTRACT: Karyotype analysis of S. cerevisiae chromosome replacement lines - alpha-type cells

PROVIDER: PRJNA114141 | ENA |

REPOSITORIES: ENA

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Karyotype analysis of S. cerevisiae chromosome replacement lines

Project description:This SuperSeries is composed of the following subset Series: GSE12775: Karyotype analysis of S. cerevisiae chromosome replacement lines - a-type cells GSE12776: Karyotype analysis of S. cerevisiae chromosome replacement lines - alpha-type cells Refer to individual Series

2008-09-16 | E-GEOD-12785 | biostudies-arrayexpress

Karyotype analysis of S. cerevisiae chromosome replacement lines - alpha-type cells

Project description:The S. cerevisiae hybrid karyotypes were analyzed by array-CGH to identify small regions of duplication or homeologous chromosomal exchange occurring during the strain construction. alpha-type cells. S. cerevisiae vs. Chromosome replacement lines. Biological replicates: 1 control (S. bayanus), 11 Chromosome replacement lines, independently grown and harvested. Two replicate per array.

2010-06-25 | E-GEOD-12776 | biostudies-arrayexpress

Karyotype analysis of S. cerevisiae chromosome replacement lines - a-type cells

Project description:Karyotype analysis of S. cerevisiae chromosome replacement lines - a-type cells

| PRJNA114139 | ENA

Karyotype analysis of S. cerevisiae chromosome replacement lines - a-type cells

Project description:The S. cerevisiae hybrid karyotypes were analyzed by array-CGH to identify small regions of duplication or homeologous chromosomal exchange occurring during the strain construction. a-type cells. S. cerevisiae vs. Chromosome replacement lines. Biological replicates: 1 control (S. bayanus), 11 Chromosome replacement lines, independently grown and harvested. Two replicate per array.

2010-06-25 | E-GEOD-12775 | biostudies-arrayexpress

Karyotype analysis of S. cerevisiae chromosome replacement lines - alpha-type cells

2008-09-16 | GSE12776 | GEO

Karyotype analysis of S. cerevisiae chromosome replacement lines - a-type cells

2008-09-16 | GSE12775 | GEO

Project description:Karyotype analysis of S. cerevisiae chromosome replacement lines

| PRJNA112779 | ENA

Karyotype analysis of S. cerevisiae chromosome replacement lines

Project description:This SuperSeries is composed of the SubSeries listed below.

2008-09-16 | GSE12785 | GEO

Karyotype analysis of polyploid Saccharomyces cerevisiae cell lines

Project description:The polyploid S. cerevisiae karyotypes were analyzed by array-CGH to identify the deletion or duplication of gene or chromosome during the strain construction and after experimental evolution.

2016-10-11 | GSE76595 | GEO

AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping features

Project description:AML with mutated NPM1 usually carries normal karyotype (NK) but it may harbor chromosomal aberrations whose significance remains unclear. We addressed this question in 631 AML patients with mutated/cytoplasmic NPM1. An abnormal karyotype (AK) was present in 93/631 cases (14.7%), the most frequent abnormalities being +8, +4, -Y, del(9q), +21. Chromosome aberrations in NPM1-mutated AML were similar to, but occurred less frequently than additional chromosome changes found in other AML with recurrent cytogenetic abnormalities according to WHO classification. Four of the 31 NPM1-mutated AML patients karyotyped at different time points had NK at diagnosis but AK at relapse: del(9q) (n=2), t(2;11) (n=1), inv(12) (n=1). NPM1-mutated AML with NK or AK showed overlapping morphological, immunophenotypic (CD34-negativity) and gene expression profile (downregulation of CD34 and upregulation of HOX genes). No difference in survival was observed among NPM1-mutated AML patients independently of whether they carried a normal or abnormal karyotype, the NPM1-mutated/FLT3-ITD negative cases showing the better prognosis. Findings in our patients point to chromosomal aberrations as secondary events, reinforce the concept that NPM1 mutation is a founder genetic lesion and indicate that NPM1-mutated AML should be clinically handled as one entity, irrespective of the karyotype.

2009-06-01 | GSE16015 | GEO

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