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Evaluation of bovine colostrum extracellular vesicles on NASH mouse model

ABSTRACT: Evaluation of bovine colostrum extracellular vesicles on NASH mouse model

PROVIDER: PRJNA1142463 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30051500_1.fastq.gz	Fastqsanger.gz
	SRR30051500_2.fastq.gz	Fastqsanger.gz
	SRR30051501_1.fastq.gz	Fastqsanger.gz
	SRR30051501_2.fastq.gz	Fastqsanger.gz
	SRR30051502_1.fastq.gz	Fastqsanger.gz

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Evaluation of bovine colostrum extracellular vesicles on NASH mouse model

Project description:The potential of orally administered colostrum-derived EVs to regulate gut microbiota dysbiosis and prevent non-alcoholic steatohepatitis was evaluated. The results demonstrated that colostrum-derived EVs improved steatosis, fibrosis, and inflammation. Transcriptome analysis showed decreased lipid metabolism, bacterial response, and inflammatory responses in the intestine, and reduced inflammatory and fibrosis-related pathways in the liver. Gut microbiota and metabolite analysis revealed an increased abundance of Akkermansia and elevated cholesterol excretion. Additionally, treatment with colostrum-derived EVs increased the production of tight junction proteins and mucin in the intestine. These findings suggest that increased Akkermansia due to colostrum-derived EVs improves intestinal inflammation and barrier function, preventing endotoxin translocation to the liver and thereby reducing liver inflammation and fibrosis.

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