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A novel anti-epileptogenesis strategy of temporal lobe epilepsy based on nitric oxide donor

ABSTRACT: A novel anti-epileptogenesis strategy of temporal lobe epilepsy based on nitric oxide donor

PROVIDER: PRJNA1145909 | ENA |

REPOSITORIES: ENA

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A novel anti-epileptogenesis strategy of temporal lobe epilepsy based on nitric oxide donor

Project description:The molecular mechanism underlying the role of hippocampal hilar interneuron degeneration in temporal lobe epilepsy (TLE) remains unclear. Especially, very few studies have focused on the role of neuronal nitric oxide synthase (nNOS, encoded by Nos1) containing hilar interneurons in TLE. In the present study, Nos1 conditional knockout mice were constructed, and we found that selective deletion of Nos1 in hilar interneurons rather than dentate granular cells (DGCs) triggered epileptogenesis. The level of nNOS was downregulated in patients and mice with TLE. Nos1 deletion led to excessive epilepsy-like excitatory input circuit formation and hyperexcitation of DGCs. Replenishment of hilar nNOS protein blocked epileptogenic development and memory impairment in pilocarpine-induced TLE mice. Moreover, chronic treatment with DETA/NONOate, a slowly released exogenous nitric oxide (NO) donor, prevented aberrant neural circuits of DGCs and the consequent epileptogenesis without acute antiseizure effects. Therefore, we concluded that NO donor therapy may be a novel anti-epileptogenesis strategy, different from existing antiseizure medications (ASMs), for curing TLE.

2024-10-21 | GSE274303 | GEO

A novel anti-epileptogenesis strategy of temporal lobe epilepsy based on nitric oxide donor

Project description: Not available

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Temporal neocortex mesial temporal lobe epilepsy

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Temporal lobe epilepsy and Alzheimer's disease

Project description:This SuperSeries is composed of the following subset Series: GSE6771: Temporal Cortex Control (mesial temporal lobe epilepsy control) GSE6773: Temporal neocortex mesial temporal lobe epilepsy GSE6774: Temporal Cortex Control (Alzheimer's disease control) GSE6775: Temporal Cortex Alzheimer's Disease GSE6777: Cerebellum Alzheimer's Disease GSE6778: Cerebellum Control (Alzheimer's disease control) Keywords: SuperSeries Refer to individual Series

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Global expression profiling of hippocampus in a mouse model for Mesio-Temporal Lobe Epilepsy

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