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Spatiotemporal dynamics of the developing zebrafish enteric nervous system at the whole organ level

ABSTRACT: Spatiotemporal dynamics of the developing zebrafish enteric nervous system at the whole organ level

PROVIDER: PRJNA1146366 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30186672_1.fastq.gz	Fastqsanger.gz
	SRR30186672_2.fastq.gz	Fastqsanger.gz
	SRR30186673_1.fastq.gz	Fastqsanger.gz
	SRR30186673_2.fastq.gz	Fastqsanger.gz
	SRR30186674_1.fastq.gz	Fastqsanger.gz

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Spatiotemporal dynamics of the developing zebrafish enteric nervous system at the whole organ level

Project description:Neural crest cells give rise to the neurons of the enteric nervous system (ENS) that innervate the gastrointestinal tract to regulate gut motility. The immense size and distinct subregions of the gut present a challenge to understanding the spatial organization and sequential differentiation of different neuronal subtypes. Here, we profile enteric neurons and progenitors at single cell resolution during zebrafish embryonic and larval development to provide a near complete picture of transcriptional changes that accompany emergence of ENS neurons throughout the gastrointestinal tract. Multiplex spatial RNA transcript analysis reveals the temporal order and distinct localization patterns of neuronal subtypes along the length of the gut. Finally, we show that functional perturbation of select transcription factors Ebf1a, Gata3 and Satb2 alters the cell fate choice, respectively, of inhibitory, excitatory and serotonergic neuronal subtypes in the developing ENS.

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