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Ribotag-RNA sequencing data using Csde1-KD dorsal root ganglion(DRG) neurons

ABSTRACT: Ribotag-RNA sequencing data using Csde1-KD dorsal root ganglion(DRG) neurons

PROVIDER: PRJNA1147294 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30214339_1.fastq.gz	Fastqsanger.gz
	SRR30214340_1.fastq.gz	Fastqsanger.gz
	SRR30214341_1.fastq.gz	Fastqsanger.gz
	SRR30214342_1.fastq.gz	Fastqsanger.gz
	SRR30214343_1.fastq.gz	Fastqsanger.gz

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Ribotag-RNA sequencing data using Csde1-KD dorsal root ganglion(DRG) neurons

Project description:We found that the expression of various ribosomal protein genes is regulated at the translation level, and the post-transcriptional regulator CSDE1 controls their association with ribosomes after sciatic nerve injury. This sequencing data shows neurons without CSDE1 exhibit a deficiency in the recruitment of ribosomal protein mRNAs to ribosomes.

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Project description:We generated whole-genome gene expression profiles of dorsal root ganglion (DRG) neurons following nerve damage. DRG neurons extend one peripheral axon into the spinal nerve and one central axon into the dorsal root. The peripheral axon regenerates vigorously, while in contrast the central axon has little regenerative capacity. For this study, two groups of animals were subjected either to sciatic nerve (SN) or dorsal root (DR) crush, and at 12, 24, 72 hours and 7 days after the crush, lumbar DRGs L4, L5 and L6 were dissected and total RNA was extracted. For each time point after lesion, three biological replicate RNA samples were hybridized together with the common reference sample consisting of labeld RNA pooled from three unlesioned animals.

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