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P26 condensates from Pea enation mosaic virus 2 sequester ribosomal components and suppress translation

ABSTRACT: p26 condensates from Pea enation mosaic virus 2 sequester ribosomal components and suppress translation

PROVIDER: PRJNA1151067 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30344561_1.fastq.gz	Fastqsanger.gz
	SRR30344561_2.fastq.gz	Fastqsanger.gz
	SRR30344562_1.fastq.gz	Fastqsanger.gz
	SRR30344562_2.fastq.gz	Fastqsanger.gz
	SRR30344563_1.fastq.gz	Fastqsanger.gz

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p26 condensates from Pea enation mosaic virus 2 sequester ribosomal components and suppress translation

Project description:The p26 movement protein of Pea enation mosaic virus 2 (PEMV2) interacts with the 2'-O-methyltransferase fibrillarin within nuclear and cytoplasmic condensates. This study analyzed global 2'-O-methylation patterns in PEMV2-infected Nicotiana benthamiana using RiboMethSeq, focusing on ribosomal RNAs (rRNAs). The aim was to assess whether PEMV2 disrupts rRNA 2'-O-methylation to interfere with host translation or ribosome assembly.

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Disruption of nonsense-mediated decay by the multifunctional long-distance movement protein of Pea enation mosaic virus 2

Project description:Nonsense-mediated decay (NMD) is an RNA regulatory pathway that degrades both natural and faulty messenger RNAs with long 3’ untranslated regions. NMD targets diverse families of RNA viruses, forcing viruses to counteract the NMD pathway for successful amplification in host cells. Using a transcriptome-wide approach in the model plant Nicotiana benthamiana, We report that the Pea enation mosaic virus 2 long-distance movement protein, p26, protects a subset of natural cellular NMD-target transcripts, particularly those containing long, structured, GC-rich 3’ UTRs. Furthermore, RNA-seq revealed that the NMD pathway is highly dysfunctional during PEMV2 infection, with nearly half of NMD-targets increasing in abundance. Widespread changes in host transcriptomes are common during RNA virus infections and these results suggest that virus-mediated NMD-inhibition may be a major contributing factor.

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Project description:Drosophila melanogaster mei-P26, meiotic P26, is differentially expressed in 17 experiment(s);

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Transcription profiling of Arabidopsis wild type, AtVdac1 knock-outs, p26 knock-outs and AtVdac1-p26 double kock-outs in response to growth in medium with salicylic acid

Project description:Functions of AtVDAC1 and its partner p26 in Arabidopsis thaliana. We previously showed that knock-out mutants impaired in AtVdac1 and p26 (AtVdac1 protein partner) are hypersensitive to salicylic acid: the root growth is more inhibited in response to 30 uM salicylic acid (SA) compared to the wild type. We want to know now which genes are up- or down-regulated in the mutants in control and SA conditions.<br> We want to compare the RNAm contents in the wild type, vdac1 and p26 mutants and, vdac1-p26 double mutant. One-week old plantlets were transferred for 2 hours on a fresh medium containing either 0 or 30uM salicylic acid.<br> Arabidopsis lines (WT, vdac1.1, p26.1, vdac1.1-p26.1) were grown in vertical position on ABIS medium (Lanquar et al., 2006). One week-old seedlings were transferred on a fresh ABIS medium containing either 0 or 30 uM salicylic acid. After 2 hours, the all seedlings were harvested. Three replicates were done; total RNAs from these 3 experiments were mixed together for the transcriptomic analysis.

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