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ABSTRACT: Enhanced production of phenolic acids and tanshinones in hairy roots culture of Salvia miltiorrhiza Bunge by the auxin elicitation

PROVIDER: PRJNA1176199 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31075772_1.fastq.gz	Fastqsanger.gz
	SRR31075772_2.fastq.gz	Fastqsanger.gz
	SRR31075773_1.fastq.gz	Fastqsanger.gz
	SRR31075773_2.fastq.gz	Fastqsanger.gz
	SRR31075774_1.fastq.gz	Fastqsanger.gz

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Comprehensive transcriptome profiling of Salvia miltiorrhiza for discovery of downstream and regulatory genes involved in tanshinone and phenolic acid biosynthesis

Project description:Tanshinones and phenolic acids are crucial bioactive compounds biosynthesized in Salvia miltiorrhiza. Methyl jasmonate (MeJA) is an effective elicitor to enhance the production of phenolic acids and tanshinones simultaneously, while yeast extract (YE) is used as a biotic elicitor that only induce tanshinones accumulation. However, little was known about the different molecular mechanism. To identify the downstream and regulatory genes involved in tanshinone and phenolic acid biosynthesis, we conducted comparative transcriptome profiling of S. miltiorrhiza hairy roots treated with either MeJA or YE.Total 55588 unigenes were assembled from about 1.72 billion clean reads, of which 42458 unigenes (76.4%) were successfully annotated. The expression patterns of 19 selected genes in the significantly upregulated unigenes were verified by quantitative real-time PCR. The candidate downstream genes and other cytochrome P450s involved in the late steps of tanshinone and phenolic acid biosynthesis pathways were screened from the RNA-seq dataset based on co-expression pattern analysis with specific biosynthetic genes. Additionally, 375 transcription factors were identified to exhibit a significant up-regulated expression pattern in response to induction. This study can provide us a valuable gene resource for elucidating the molecular mechanism of tanshinones and phenolic acids biosynthesis in hairy roots of S.miltiorrhiza.

2017-09-14 | GSE100970 | GEO

Project description:Salvia miltiorrhiza hairy roots transcriptome

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Microarray analysis of the therapeutic effects of the mixture of salvianolic acids from Salvia miltiorrhiza and total flavonoids from Anemarrhena asphodeloides on sulfur mustard-induced damages

Project description:To further investigate the potential molecular basis of the therapeutic effects of the mixture of salvianolic acids from Salvia miltiorrhiza and total flavonoids from Anemarrhena asphodeloides (MSTF) on sulfur mustard (SM) damage, gene expression analysis was conducted on rats liver tissues using microarrays.

2014-11-05 | GSE62994 | GEO

Project description:endophytic fungi community of Salvia miltiorrhiza Bunge

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RNA sequencing of RAW264.7 with or without Sal-B and LPS addition

Project description:Autologous fat grafting (AFG), although an appealing approach to repair soft tissue defects, has various complications. Excessive inflammation at the transplant site is one of the main reasons for the poor effect of fat transplantation and occurrence of complications. Our previous study proved that Salvia miltiorrhiza can enhance fat graft survival. Salvianolic acid B (Sal-B) is the most abundant and bioactive water-soluble compound in Salvia miltiorrhiza and has anti-inflammatory effects on other diseases. Therefore, we hypothesized that salvianolic acid B could improve the effect of fat grafts by inhibiting inflammation.

2023-09-14 | GSE186886 | GEO

Project description:Endophytic fungus influences hairy root of Salvia miltiorrhiza

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Project description:Salvia miltiorrhiza miRNAs in miR396b overexpression hairy roots and control hairy roos

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Project description:Transcript profiling of Smi-miR396b overexpression Salvia miltiorrhiza hairy roots

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A gDNA microarray for genotyping Salvia species

Project description:Salvia is an important genus from the Lamiaceae with approximately 1000 species distributed globally. Several Salvia species are commercially important because of their medicinal and culinary properties. We report the construction of the first fingerprinting array for Salvia species enriched with polymorphic and divergent DNA sequences and demonstrate the potential of this array for fingerprinting several economically important members of this genus. In order to generate the Salvia Subtracted Diversity Array (SDA), a Suppression Subtractive Hybridization (SSH) was performed between a pool of ten Salvia species and a pool of non-angiosperm and angiosperms (excluding the Lamiaceae) to selectively isolate Salvia-specific sequences. A total of 285 subtracted genomic DNA (gDNA) fragments were amplified and arrayed. DNA fingerprints were obtained for fifteen Salvia genotypes including three that were not part of the original subtraction pool. Hierarchical cluster analysis indicated that the Salvia-specific SDA was capable of differentiating closely related species of S. officinalis and S. miltiorrhiza and was also able to reveal genetic relationships consistent with geographical origins. Species-specific features were also found for S. elegans, S. officinalis, S. sclarea, S. przewalskii and S. runcinata.

2013-07-31 | E-GEOD-39403 | biostudies-arrayexpress

Proteomic and metabonomic analyses to reveal the underlying molecular mechanism of phenolic acids accumulation in leaves of Salvia miltiorrhiza under UV-B radiation

Project description:Salvianolic acid is the secondary metabolic products of Salvia miltiorrhiza, and its biosynthesis is induced and regulated by all kinds of abiotic factors. Our results showed that content of salvianolic acid including caftaric acid, salvianolic acid B, roamarinic acid, and salvianolic acid H was increased more than 50 times by UV-B radiation in leaves of Salvia miltiorrhiza. Further proteomic analysis identified 436 significantly proteins which are contributed to salvianolic acid accumulation under UV-B radiation. Among of them, photosynthesis related proteins were decreased, protein processing and phenolic acids synthesis related confirmed and potential key enzymes including cinnamoyl-CoA reductase, rosmarinic acid synthase, phenylalanine ammonia-lyase, were increased in UV-B treated danshen

2018-04-17 | PXD017135 |

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