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MiRNA expression profiles in the dorsal striatum of a mouse model of nicotine withdrawal

ABSTRACT: miRNA expression profiles in the dorsal striatum of a mouse model of nicotine withdrawal

PROVIDER: PRJNA1180203 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31177226.fastq.gz	Fastqsanger.gz
	SRR31177227.fastq.gz	Fastqsanger.gz
	SRR31177228.fastq.gz	Fastqsanger.gz
	SRR31177229.fastq.gz	Fastqsanger.gz
	SRR31177230.fastq.gz	Fastqsanger.gz

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miRNA expression profiles in the dorsal striatum of a mouse model of nicotine withdrawal

Project description:Nicotine withdrawal can diversely affect brain gene expression patterns. In the brain, the dorsal striatum is a hub of nicotine dependence. Previous studies have shown that nicotine dependence leads to functional alterations in the dorsal striatum. miRNAs are small non-coding RNAs that regulates cellular functions and dysfunctions. Here, we performed small RNA sequencing from the dorsal striatum of mice at 7 days after nicotine withdrawal. Our results show that nicotine withdrawal does not notably impact miRNA expression profile in the dorsal striatum, but a few miRNAs were significantly altered in response to nicotine withdrawal. These results suggest that nicotine withdrawal has a small but significant impact on the miRNA expression profile in the mouse dorsal striatum.

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Integrated miRNA/mRNA-Seq of the Habenulo-Interpeduncular Withdrawal Circuit

Project description:Nicotine dependence is responsible for perpetuating the adverse health effects due to tobacco use, the leading cause of preventable death worldwide. Nicotine is an agonist for nicotinic acetylcholine receptors, which are enriched in the habenulo-interpeduncular withdrawal circuit. Drugs of abuse, including nicotine, induce stable neuroadaptations, requiring protein synthesis through regulation of transcription factors, epigenetic mechanisms, and non-coding RNAs. It also been shown that miRNAs in brain are regulated by nicotine and that miRNA dysregulation contributes to brain dysfunction, including drug addiction. While much is known about the neurocircuitry responsible for the behaviors associated with nicotine reward or withdrawal, the underlying mechanisms of how changes in behavior are induced are less clear. Using miRNA- and mRNA-Seq, we demonstrate that there are widespread changes in both miRNA and mRNA expression in the IPN and MHb during acute nicotine withdrawal. Conserved, differentially expressed miRNAs were predicted to target inversely regulated mRNAs. This dataset represents a valuable resource, identifying a multitude of miRNAs/genes, which upon further study may reveal new mechanisms underlying the neuroadaptations of nicotine dependence and the symptoms of nicotine withdrawal.

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Project description:We used microarrays to determine the effect of prenatal nicotine exposure on gene expression profiles in the striatum of adolescent rats. We found a number of immediate early genes to be differentially expressed due to food-restriction. We compared control (n=8), nicotine exposed (n=7) and a group of animals matched to the food intake of nicotine exposed animals (n=10) to identify gene expression changes associated with prenatal nicotine exposure

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Gestational food-restriction but not nicotine exposure regulates gene expression in the striatum of adolescent rats

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