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Actinobacillus pleuropneumoniae strain:Swine lung | isolate:Swine lung

ABSTRACT: Actinobacillus pleuropneumoniae strain:Swine lung | isolate:Swine lung Genome sequencing

PROVIDER: PRJNA1182842 | ENA |

REPOSITORIES: ENA

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Actinobacillus pleuropneumoniae strain:Swine lung | isolate:Swine lung

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Actinobacillus pleuropneumoniae BHI vs Koromycin

Project description:Actinobacillus pleuropneumoniae is the etiologic agent of contagious pleuropneumonia, an economically important disease of commercially reared swine throughout the world. To cause this disease, A. pleuropneumoniae must rapidly overcome porcine pulmonary innate immune defenses. Effects of koromycin, an antimicrobial agent that acts as an noncompetitive inhibitor of the interaction of NQR with its quinone substrate, on the transcriptome of A. pleuropneumoniae was investigated.

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Actinobacillus pleuropneumoniae strain:lung | isolate:lung

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Project description:This study aimed at: (1) Establishing the pleuropneumoniae pathological model of artificial infection; (2) Using the Agilent swine genome-wide microarray containing 43,603 probes to detect the changes in gene expression of infected pigsM-bM-^@M-^Y lungs and hilar nodes. Infection induced gene expression in swine lung and hilar node were measured at 48 hours after being inoculated with 1 mL containing 3.8 M-CM-^W 10^7 cfu/mL pleuropneumoniae serotype I by atomizing inhalation in each nostril.

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