Project description:We set out to test the hypothesis that formaldehyde inhalation exposure significantly alters miRNA expression profiles within the nasal epithelium of nonhuman primates. Here, cynomolgus macaques were exposed to 0, 2, and 6 ppm formaldehyde for 6 hours/day across two consecutive days. RNA was extracted from the nasal maxilloturbinate region, a direct target of formaldehyde inhalation exposure. Genome-wide miRNA expression levels were assessed using microarrays.

2012-09-01 | GSE34978 | GEO

Transcriptomes of normal aging brains in female nonhuman primates.

Project description:Transcriptomes of normal aging brains in female nonhuman primates.

| PRJNA883201 | ENA

Molecular analysis of aging heart in female nonhuman primates.

Project description:Molecular analysis of aging heart in female nonhuman primates.

| PRJNA1026653 | ENA

DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Project description:<p>Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysregulated glycine metabolism has emerged as a causative factor and therapeutic target in NASH. Here, we report that the tripeptide DT-109 (Gly-Gly-Leu) dose-dependently attenuates steatohepatitis and fibrosis in mice. To enhance the probability of successful translation, we developed a nonhuman primate model that histologically and transcriptionally mimics human NASH. Applying a multiomics approach combining transcriptomics, proteomics, metabolomics and metagenomics, we found that DT-109 reverses hepatic steatosis and prevents fibrosis progression in nonhuman primates, not only by stimulating fatty acid degradation and glutathione formation, as found in mice, but also by modulating microbial bile acid metabolism. Our studies describe a highly translatable NASH model and highlight the need for clinical evaluation of DT-109.</p>

2023-04-13 | MTBLS5005 | MetaboLights

Host response and dysfunction in the CNS during chronic simian immunodeficiency virus infection

Project description:Molecular basis for CNS dysfunction in simian immunodeficiency virus-infected rhesus monkeys. We used microarrays to identify differentially expressed genes in chronic simian immunodeficiency virus-infected rhesus monkeys. Frontal lobe samples were obtained from control and SIV infected animals for RNA extraction and hybridization on Affymetrix microarrays. We sought to better understand the gene that changes in gene expression with SIV infection in the frontal lobe.

2012-01-29 | E-GEOD-35397 | biostudies-arrayexpress

Simian immunodeficiency virus

Project description:Simian immunodeficiency virus Genome sequencing and assembly

| PRJNA317777 | ENA