Danio rerio
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA118365 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Biological variation between zebrafish development series
| PRJNA118361 | ENA
Project description:Fathead minnow and zebrafish are among the most intensively studied fish species in environmental toxicogenomics. To aid the assessment and interpretation of subtle transcriptomic effects from treatment conditions of interest, there needs to be a better characterization and understanding of the natural variation in gene expression among fish individuals within populations. Little effort, however, has been made in this area. Leveraging the transcriptomics data from a number of our toxicogenomics studies conducted over the years, we conducted a meta-analysis of nearly 600 microarrays generated from the ovary tissue of untreated, reproductively mature fathead minnow and zebrafish samples. As expected, there was considerable batch-to-batch transcriptomic variation; this “batch-effect” appeared to impact the fish transcriptomes randomly. The overall level of variation within-batch was quite low in fish ovary tissue, making it a suitable system for studying chemical stressors with subtle biological effects. The within-batch variation, however, differed considerably among individual genes and molecular pathways. This difference in variability is probably both technical and biological, thus suggesting a need to take into account both the expression levels and variance in evaluating and interpreting the transcriptional impact on genes and pathways by experimental conditions. There was significant conservation of both the genomes and transcriptomes between fathead minnow and zebrafish. The conservation to such a degree would enable not only a comparative biology approach in studying the mechanisms of action underlying environmental stressors, but also effective sharing of a large amount of existing public transcriptomics data for future development of toxicogenomics applications.
2015-08-01 | GSE60167 | GEO
Project description:Using individual coping styles to explain within-population variation in adaptive gene expression
| PRJNA174726 | ENA
Project description:Pair wise comparison between STD-MO and klf4-MO embryos
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Project description:Comparison of expression data between control and Ovo1 morphant zebrafish embryos
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Project description:Genome-wide epigenetic cross-talk between DNA methylation and H3K27me3 in zebrafish embryos
| PRJNA289683 | ENA
Project description:Identification of differentially-expressed genes between FoxH1 morpholino and control in zebrafish embryos.
| PRJNA100913 | ENA
Project description:Comparison of expression data between control and Bdh2 morphant zebrafish embryos, as well as Bdh2 morphant zebrafish embryos expressing ectopic Bdh2
| PRJNA307594 | ENA
Project description:RNA-sequencing of neural crest cells collected from Gt(foxd3:mCherry);Tg(sox10:mEGFP) embryos
2019-09-05 | GSE135237 | GEO
Project description:Comparison of expression data between control, Atg7, Bdh2, Atg7 and Bdh2 dual morphant zebrafish embryos
| PRJNA307595 | ENA