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DNA Methylation profiles of subjects in the Healthy Brain Initiative study.

ABSTRACT: DNA Methylation profiles of subjects in the Healthy Brain Initiative study.

PROVIDER: PRJNA1183840 | ENA |

REPOSITORIES: ENA

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DNA Methylation profiles of subjects in the Healthy Brain Initiative study.

Project description:The Healthy Brain Initiative (HBI) is a longitudinal study focused on older adults in South Florida, with the goal of advancing dementia prevention and promoting brain health. We generated DNA methylation profiles for 88 HBI participants aged over 65. The Illumina MethylationEPIC v2.0 Beadchip was used to obtain DNA methylation profiles across approximately 935k CpGs from human blood samples.

2024-11-08 | GSE281429 | GEO

Transcription profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects

Project description:Down syndrome (DS) is the result of trisomy chromosome 21 but the mechanisms by which the genotype leads to the characteristic disease phenotype are unclear. We performed a microarray study using human adult brain tissue (dorsolateral prefrontal cortex) from DS subjects and healthy controls to characterise for the first time the human adult Down syndrome brain Experiment Overall Design: RNA extracted from human postmortem brain tissue from adult subjects with Down syndrome and healthy controls was hybridised to Affymetrix HG-U133A GeneChips to identify differentially expressed genes in the disease state.

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Expression profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects

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Transcription profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls

Project description:This SuperSeries is composed of the following subset Series:; GSE5388: Adult postmortem brain tissue (dorsolateral prefrontal cortex) in subjects with bipolar disorder; GSE5389: Adult postmortem brain tissue (ortibtofrontal cortex) in subjects with bipolar disorder; Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex and orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls. Experiment Overall Design: Refer to individual Series

2008-06-13 | E-GEOD-5392 | biostudies-arrayexpress

Adult postmortem brain tissue (orbitofrontal cortex) from subjects with bipolar disorder and healthy controls

Project description:Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls. Orbitofrontal cortex tissue from a cohort of 30 subjects was investigated and the final analysis included 10 bipolar and 11 control subjects. Differences between disease and control groups were identified using a rigorous statistical analysis with correction for confounding variables and multiple testing. Keywords: disease state analysis

2006-07-27 | GSE5389 | GEO

Adult postmortem brain tissue (dorsolateral prefrontal cortex) from subjects with bipolar disorder and healthy controls

Project description:Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex) from patients with bipolar disorder and matched healthy controls. A cohort of 70 subjects was investigated and the final analysis included 30 bipolar and 31 control subjects. Differences between disease and control groups were identified using a rigorous statistical analysis with correction for confounding variables and multiple testing. Keywords: disease state analysis

2006-07-27 | GSE5388 | GEO

Sotos syndrome and healthy control subjects

Project description:Sotos syndrome and healthy control subjects

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Neutrophil activation phenotypes in healthy subjects

Project description:Neutrophil activation phenotypes in healthy subjects

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Transcription profiling of human brain tissue from subjects with bipolar disorder and healthy controls

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2007-06-24 | E-GEOD-5388 | biostudies-arrayexpress

Neutrophil activation phenotypes in healthy subjects

Project description:RNA was extracted from neutrophils from healthy subjects whose neutrophil function has been extensively characterized for RNA sequencing.

2022-03-06 | GSE197823 | GEO

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