Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: The novel HLA-DRB1 allele is found through Pacbio sequencing in Sino-Us-Diagnostics Lab

PROVIDER: PRJNA1188809 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31420718_subreads.fastq.gz	Fastqsanger.gz

Items per page:

1 - 1 of 1

Similar Datasets

Project description:The novel HLA-C allele is found through Pacbio sequencing in Sino-US Diagnostics Lab

| PRJNA1192561 | ENA

Project description:The novel HLA-DPA1 allele is found through Pacbio sequencing in Sino-US Diagnostics Lab

| PRJNA1174422 | ENA

Project description:A new HLA-DRB4 allele is found through Pacbio sequencing in Sino-US Diagnostics Lab

| PRJNA1148336 | ENA

Project description:A new HLA-DPB1 allele is found through Pacbio sequencing in Sino-US Diagnostics Lab

| PRJNA1137127 | ENA

Project description:A new HLA-DPA1 allele is found through Pacbio sequencing in Sino-US Diagnostics Lab

| PRJNA1147867 | ENA

Project description:A new HLA-A allele is found through Pacbio sequencing in Sino-US Diagnostics Lab,

| PRJNA1146980 | ENA

Project description:The novel HLA_DPB1 allele is found through Pacbio sequencing in Sino-US Diagnostics Lab

| PRJNA1172871 | ENA

Project description:a novel HLA-A allele found

| PRJEB25142 | ENA

A new HLA-DRB1*07 allele, identified in a Chinese individual

Project description:A new HLA-DRB1*07 allele

| PRJEB21367 | ENA

Expression levels of HLA-DRB and HLA-DQ are associated with MHC Class II haplotypes in healthy individuals and rheumatoid arthritis patients

Project description:HLA-DRB1 alleles have been associated with several autoimmune diseases. In anti-citrullinated protein antibody positive rheumatoid arthritis (ACPA-positive RA), HLA-DRB1 shared epitope (SE) alleles are the major genetic risk factors. In order to investigate whether expression of different alleles of major histocompatibility complex (MHC) Class II genes influence functions of immune cells, we investigated transcriptomic profiles of a variety of immune cells from healthy individuals carrying different HLA-DRB1 alleles. Sequencing libraries from peripheral blood mononuclear cells, CD4+ T cells, CD8+ T cells, and CD14+ monocytes of 32 genetically pre-selected healthy female individuals were generated, sequenced and reads were aligned to the standard reference. For the MHC region, reads were mapped to available MHC reference haplotypes and AltHapAlignR was used to estimate gene expression. Using this method, HLA-DRB and HLA-DQ were found to be differentially expressed in different immune cells of healthy individuals as well as in whole blood samples of RA patients carrying HLA-DRB1 SE-positive versus SE-negative alleles. In contrast, no genes outside the MHC region were differentially expressed between individuals carrying HLA-DRB1 SE-positive and SE-negative alleles. Existing methods for HLA-DR allele-specific protein expression were evaluated but were not mature enough to provide appropriate complementary information at the protein level. Altogether, our findings suggest that immune effects associated with different allelic forms of HLA-DR and HLA-DQ may be associated not only with differences in the structure of these proteins, but also with differences in their expression levels.

2020-12-22 | GSE163605 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data