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ABSTRACT: The novel HLA-C allele is found through Pacbio sequencing in Sino-US Diagnostics Lab

PROVIDER: PRJNA1192561 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31559815_subreads.fastq.gz	Fastqsanger.gz

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Analysis of human leukocyte antigen (HLA) allotype-specific response in abacavir-exposed keratinocyte

Project description:Abacavir, a nucleoside reverse-transcriptase inhibitor used for the treatment of human immunodeficiency virus (HIV) infection, develops hypersensitivity in patients carrying HLA-B*57:01 allele through drug antigen presentation. We found that abacavir exposure induced HLA allotype-specific innate immune response in keratinocyte derived from HLA-B*57:01 transgenic mice. Therefore, the mechanism of the novel response was analyzed comprehensively.

2018-03-01 | GSE110394 | GEO

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