Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Control of Striatal Circuit Development by the Chromatin Regulator Zswim6 [snRNA-Seq]

ABSTRACT: Control of Striatal Circuit Development by the Chromatin Regulator Zswim6 [snRNA-Seq]

PROVIDER: PRJNA1190482 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31506800.fastq.gz	Fastqsanger.gz
	SRR31506801.fastq.gz	Fastqsanger.gz
	SRR31506802.fastq.gz	Fastqsanger.gz
	SRR31506803.fastq.gz	Fastqsanger.gz
	SRR31506804.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 44

Similar Datasets

Control of Striatal Circuit Development by the Chromatin Regulator Zswim6 [snRNA-Seq]

Project description:The pathophysiology of neurodevelopmental disorders involves vulnerable neural populations, including striatal circuitry, and convergent molecular nodes, including chromatin regulation and synapse function. Despite this, how epigenetic regulation regulates striatal development is understudied. Recurrent de novo mutations in Zswim6 are associated with intellectual disability and autism. We demonstrate that ZSWIM6 localizes to the nucleus where it associates with repressive chromatin regulators. Disruption of Zswim6 in ventral telencephalic progenitors leads to increased chromatin accessibility and transcriptional dysregulation. Ablating Zswim6 in either striatal direct or indirect pathway spiny projection neurons resulted in similar cell-autonomous changes in excitatory but not inhibitory synaptic transmission. Specifically, Zswim6 disruption altered the desensitization properties of AMPA receptors, leading to enhanced synaptic recruitment of SPNs, explaining SPN-subtype specific effects on activity and behavioral sub-structure. Finally, adult deletion of Zswim6 identified a continuing role in the maintenance of mature striatal synapses. Together, we describe a mechanistic role for Zswim6 in the epigenetic control of striatal synaptic development.

2024-11-25 | GSE282825 | GEO

Control of Striatal Circuit Development by the Chromatin Regulator Zswim6 [ATAC-Seq]

Project description:Control of Striatal Circuit Development by the Chromatin Regulator Zswim6 [ATAC-Seq]

| PRJNA1190480 | ENA

Control of Striatal Circuit Development by the Chromatin Regulator Zswim6 [ATAC-Seq]

2024-11-25 | GSE282824 | GEO

PQBP1 regulates striatum development through balancing striatal progenitor proliferation and differentiation

Project description:The balance between cell proliferation and differentiation is essential for maintaining the neural progenitor pool and brain development. Although the mechanisms underlying cell proliferation and differentiation at the transcriptional level have been studied intensively, post-transcriptional regulation of cell proliferation and differentiation remains largely unclear. Here, we show that deletion of the alternative splicing regulator PQBP1 in striatal progenitors resulted in defective striatal development due to impaired neurogenesis of spiny projection neurons (SPNs). Pqbp1 deficiency striatal progenitors exhibit declined proliferation and increased differentiation, resulting in a reduced striatal progenitor pool. We further reveal that PQBP1 associates with components in splicing machinery. The alternative splicing profiles identify that PQBP1 promotes the exon 9 inclusion of Numb, a variant that mediates progenitor proliferation. These findings identify PQBP1 as a novel regulator in balancing striatal progenitor proliferation and differentiation and provide alternative insights into the pathogenic mechanisms underlying Renpenning syndrome.

2023-02-21 | GSE225486 | GEO

Generation of human induced pluripotent stem cell-derived 3D human cortical, striatal, mesencephalic and diencephalic organoids

Project description:Single cell RNA-seq characterization of stem cell derived organoids resembling the parts of human cortico-striatal-thalamo-cortical circuit

2024-10-16 | GSE279264 | GEO

Decoding the regulatory circuit by epigenetic regulator MOF in haematopoiesis

Project description:Decoding the regulatory circuit by epigenetic regulator MOF in haematopoiesis

| PRJNA419167 | ENA

Transcriptomic (RNA-seq) analysis of wild-type and Nolz1-/- (Zfp503) mutant striatal tissue reveals altered expression of several genes involved in striatal projection neuron specification.

Project description:Midbrain dopaminergic (DA) axons make long longitudinal projections towards target areas in the forebrain, including the striatum. After demonstrating a striatal specific requirement of transcriptional regulator Nolz1 (Zfp503) in regulating DA axon guidance and innervation, we performed RNA-seq analysis on both wild-type and Nolz1-/- mutant striatal tissue. The gene expression analysis revealed a requirement of Nolz1 in regulating striatal projection neuron specification. The RNA-seq results reveal several secreted factors that underlie the observed guidance defects and resulted in the identification of proteins that can restore DA axonal outgrowth.

2020-05-12 | E-MTAB-8240 | biostudies-arrayexpress

Human striatal organoids derived from pluripotent stem cells recapitulate striatal development and compartments

Project description:Human striatal organoids derived from pluripotent stem cells recapitulate striatal development and compartments

| PRJNA762311 | ENA

Foxp striatal compensation

Project description:Foxp striatal compensation

| PRJNA951694 | ENA

Identification of U1 snRNA associated proteins

Project description:In this project, we isolate U1 snRNA associated proteins in Arabidopsis thaliana. We used an antisense oligonucleotide specific for the U1 snRNA and analyzed associated proteins by mass spectrometry. As a control, the same experiments were performed with U2 snRNA- and lacZ-specifc antisense oligonucleotides.

2023-12-04 | PXD045484 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data