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Mechanism of pyroptosis of pancreatic cancer induced by arachidonic acid

ABSTRACT: Mechanism of pyroptosis of pancreatic cancer induced by arachidonic acid

PROVIDER: PRJNA1193484 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31592340_1.fastq.gz	Fastqsanger.gz
	SRR31592340_2.fastq.gz	Fastqsanger.gz
	SRR31592341_1.fastq.gz	Fastqsanger.gz
	SRR31592341_2.fastq.gz	Fastqsanger.gz
	SRR31592342_1.fastq.gz	Fastqsanger.gz

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Mechanism of pyroptosis of pancreatic cancer induced by arachidonic acid

Project description:Pancreatic cancer is one of the most deadly malignant tumors, and its treatment is scarce. This study found that arachidonic acid can induce pyroptosis of pancreatic cancer both in vitro and in vivo, and can cause immune cell infiltration. Arachidonic acid can be used as a tumor killing drug and an immunotherapy activator, which provides a new idea for the treatment of pancreatic cancer.

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HDAC5 regulates arachidonic acid metabolism via cPLA2

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Project description:Unlike class I Histone deacetylase (HDAC) members (HDAC1, 2, 3, etc.), HDAC5, a class IIa HDAC member, is downregulated in multiple solid tumors, including pancreatic cancer, and its loss is associated with unfavorable prognosis. Additionally, HDAC5’s expression correlates negatively with arachidonic acid (AA) metabolism, which is highly implicated in inflammatory responses and cancer progression. This study aimed to elucidate the role of HDAC5 in AA metabolism and its prospect in the treatment of pancreatic cancer.

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Identification of Candida albicans genes differentially expressed in the presence of arachidonic acid

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Project description:HDAC5 regulates arachidonic acid metabolism via cPLA2

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