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MRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription [SLAM-seq]

ABSTRACT: mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription [SLAM-seq]

PROVIDER: PRJNA1197500 | ENA |

REPOSITORIES: ENA

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mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription [SLAM-seq]

Project description:Several transcription inhibitors have been developed as cancer therapies. However, they show modest clinical activity highlighting that our understanding of the cellular response to transcriptional inhibition remains incomplete. Here we report that potent inhibitors of transcription not only impact mRNA output, but also markedly impair mRNA transcript localisation and nuclear export. We demonstrate that retention of newly transcribed mRNA in nuclear speckles is an adaptive response to chemically distinct transcriptional inhibitors. Retained transcripts are fully processed and accumulate in proportion to the expression level of the genes from which they emanate. The TREX mRNA export complex plays an integral role in directing nascent transcripts to nuclear speckles where they are bound to NXF1, protected from degradation, and poised for rapid export following re-initiation of transcription. Our findings provide new insights into the crosstalk between transcription and mRNA export, with important implications for drugs aiming to inhibit transcription for therapeutic gain.

2025-02-13 | GSE284174 | GEO

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

2025-02-13 | GSE183570 | GEO

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

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mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

Project description:mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

| PRJNA761339 | ENA

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

Project description:mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

| PRJNA761329 | ENA

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

Project description:mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

| PRJNA761338 | ENA

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-02-12 | GSE183571 | GEO

SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway [Larval SLAM-Itseq]

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