Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cerebral Venous Blood Flow Regulates Brain Fluid Clearance via Dural Lymphatics

ABSTRACT: Cerebral Venous Blood Flow Regulates Brain Fluid Clearance via Dural Lymphatics

PROVIDER: PRJNA1198372 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31719405_1.fastq.gz	Fastqsanger.gz
	SRR31719405_2.fastq.gz	Fastqsanger.gz
	SRR31719406_1.fastq.gz	Fastqsanger.gz
	SRR31719406_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Cerebral Venous Blood Flow Regulates Brain Fluid Clearance via Dural Lymphatics

Project description:Previous studies have shown that the vascular system regulates brain clearance via arterial blood flow and the lymphatic drainage of CSF. Here, we examined the hypothesis that cerebral venous blood flow may participate in brain clearance as an intermediate compartment between the arterial and lymphatic poles of the vascular system. Transcriptomic analyses provided insights into the molecular mechanisms driving dural lymphatic remodeling within the dura mater.

2024-12-16 | GSE284298 | GEO

Mechanical stimulation on superificial cervical lymphatics enhances cerebropsinal fluid draiange

Project description:To gain further insight into ageing-related changes in the superficial cervical lymphatics, we performed scRNA-seq on cells isolated from the superficial cervical lymphatic system.

2025-04-07 | GSE276231 | GEO

The dural innate immune barrier protects the CNS from systemic virus invasion [CD45_10X]

Project description:To investigate cellular landscape of dural immune cells, dural immune cells from 30 P28 male mice and 30 P7 male mice were FACS sorted and single-cell RNA seqs were performed

2022-07-25 | GSE209571 | GEO

Meningeal lymphatics-microglia axis regulates synaptic physiology [ligation]

Project description:Meningeal lymphatics serve as the primary outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previous studies have demonstrated that dysfunctional meningeal lymphatics evoke behavioral deficits, but the neural mechanisms underlying those behavioral changes remained elusive. Here, we show that prolonged impairment of meningeal lymphatics alters the balance of cortical excitatory and inhibitory synaptic inputs by reducing inhibitory synapses, accompanied by deficits in novelty recognition tasks. These synaptic and behavioral alterations are mediated by microglia, which exhibit transcriptomic, morphological, and functional alterations as a result of lymphatic dysfunction. Notably, microglial expression of Il6 increases, thereby mediating the reduction in inhibitory synapses via neuronal signaling. Interestingly, improving the function of meningeal lymphatics in aged mice restores the numbers of functional inhibitory synapses and cortical network activity. Our findings suggest that dysfunctional meningeal lymphatics adversely impact cortical circuitry through a microglia−IL-6-dependent mechanism, providing a potential target for the treatment of aging-associated cognitive decline.

2025-03-21 | GSE270428 | GEO

Meningeal lymphatics-microglia axis regulates synaptic physiology [acz.vehicle]

2025-05-29 | GSE285073 | GEO

Methotrexate Clearance

Project description:Methotrexate Clearance

| PRJNA76037 | ENA

Mechanical stimulation on superificial cervical lymphatics enhances cerebropsinal fluid draiange

Project description:Mechanical stimulation on superificial cervical lymphatics enhances cerebropsinal fluid draiange

| PRJNA1156027 | ENA

Different roles of dural macrophages subpopulations to systemic viral infection

Project description:To investigate different responses of dural macrophage subsets to systemic viral infection, we collected the dura mater from mice 12 h after systemic LCMV infection and macrophages were sorted

2023-04-17 | GSE229300 | GEO

RNA sequencing data of dural macrophages isolated from brains of Cx3cr1-GFP mice at different ages.

Project description:While macrophages in the meningeal compartments of the central nervous system (CNS) has been comprehensively characterized under steady state, studying their contribution to physiological and pathological processes has been severely hampered by the lack of specific targeting tools in vivo. Recent findings have shown that the dural sinus and its adjacent lymphatic vessels act as a neuroimmune interface. Notably, the cellular and functional heterogeneity of extrasinusoidal dural macrophages outside this immune hub is currently unclear. Therefore, we comprehensively characterized these cells using single-cell transcriptomics, fate mapping, confocal imaging, clonal analysis and transgenic mouse lines. Extrasinusoidal dural macrophages were clearly distinct from leptomeningeal and CNS parenchymal macrophages in terms of their origin, expansion kinetics and transcriptional profiles. Lastly, functional studies demonstrated that during autoimmune neuroinflammation, extrasinusoidal dural macrophages perform efferocytosis of granulocytes. Our results highlight a previously unappreciated myeloid cell diversity and provide insights into the brain’s innate immune system.

2024-12-20 | GSE277981 | GEO

Role of human dural fibroblasts in the angiogenic responses of human endothelial cells: an in vitro dural model for EDAS

Project description:To determine whether dural fibroblasts (DuF) under IL-1β-mediated wound conditions, release pro-angiogenic factors, and promote angiogenic properties in human endothelial cells (ECs). DuF were stimulated by pro-inflammatory cytokines interleukin (IL)-1β, and transcriptome sequencing was then used to identify the differentially expressed genes in the DuF with/without IL-1β stimulation (DuFCon/DuFIL1b)

2023-02-15 | GSE224999 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data