Project description:The VericiDx cohort is an ongoing clinical trial (241 patients (32.0% self-reported AA) enrolled as of 06/30/2023) with a focus on predicting early acute rejection and renal fibrosis post-transplantation (ClinicalTrials.gov: NCT04727788).
Project description:The present study investigated whether maternal periodontal disease modifies the microRNA expression profile in adult offspring. *************************************************************** This study was supported by the São Paulo Research Foundation (FAPESP) [grant #2019/04183-9; #2022/08872-6; #2023/03786-7; #2023/12488-0; #2023/01400-4] and CNPq [grant 151151/2023-7], São Paulo, SP, Brazil. The grants #2019/04183-9; #2023/12488-0; #2023/01400-4 and 151151/2023-7 were awarded to the author Maria Sara de Lima Coutinho Mattera. The grant #2022/08872-6 was awarded to Heloisa Macedo Sampaio. The grant #2023/03786-7 was awarded to Gabriele Fernandes Baliero. ***************************************************************
Project description:This SuperSeries is composed of the SubSeries listed below to reproduce the data and analyses from Lareau et al. 2023 Nature Genetics
Project description:Salt cress (Eutrema salsugineum, synonymously Thellungiella salsuginea) is an extremophile, a close relative of Arabidopsis. In order to understand the selective mechanisms that shape their complex traits underlying natural variation, we analyzed the physiological and proteomic differences between Shandong (SD) ecotype and Xinjiang (XJ) ecotype.
Project description:A cross-sectional study was conducted between 2012 and 2023 to collect breast tumor and tumor-adjacent normal tissue (N=48 tumor, 41 tumor-adjacent normal) from women with breast cancer. Participants were recruited through the University of Maryland Medical Center and other hospital sites within the area of Baltimore, Maryland. RNA-sequencing and whole exome sequencing was performed on these fresh-frozen tissues. Genomic DNA was extracted from frozen breast tumors and adjacent normal tissue using the Qiagen DNeasy Blood & Tissue kit and checked for quality using the Agilent Genomic DNA Screen tape assay. WES was performed by the service provider Psomagen and data processed as in Tang, et al, 2023.
Project description:To further define the role of piRNAs in the development of renal cancer, we employed piRNA microarray expression profiling as a discovery platform to identify differentially expressed piRNAs. Radical nephrectomy was performed on 3 patients with renal cancer, and the postoperative pathology was clear cell renal cell carcinoma. The cancer tissues and adjacent normal tissues of the patients were taken for piRNA sequencing. And the differentially high-expressed and differentially low-expressed piRNAs were analyzed by bioinformatics.
