Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1203745 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR31842600_1.fastq.gz | Fastqsanger.gz | |||
| SRR31842600_2.fastq.gz | Fastqsanger.gz | |||
| SRR31842700_1.fastq.gz | Fastqsanger.gz | |||
| SRR31842700_2.fastq.gz | Fastqsanger.gz | |||
| SRR31842601_1.fastq.gz | Fastqsanger.gz |
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Project description:Here, by mapping H3K27ac deposition, we analyze the active regulatory landscapes across primary GBM biopsies, normal brain tissues, and cell line counterparts. Analysis of differentially regulated enhancers, especially super-enhancers between GBM and normal brain tissues, as well as among GBM samples with matched RNA-sequencing data, uncovered unrecognized layers of oncogenic core transcriptional dependency and inter-tumor heterogeneity. Moreover, we demonstrate the functional relevance of leading candidates of super-enhancer-driven transcriptional factors, long non-coding RNAs, and druggable targets in GBM. Through profiling of transcriptional enhancers, our integrative study provides clinically relevant insights into GBM molecular classification, pathogenesis, and therapeutic innovations.
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