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Ultrasound-activated piezoelectric nanostickers for neural stem cell therapy of traumatic brain injury therapy

ABSTRACT: Ultrasound-activated piezoelectric nanostickers for neural stem cell therapy of traumatic brain injury therapy

PROVIDER: PRJNA1203906 | ENA |

REPOSITORIES: ENA

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Ultrasound-activated piezoelectric nanostickers for neural stem cell therapy of traumatic brain injury therapy

Project description:Piezoelectric stimulation can promote neuronal differentiation of neural stem cells. Here we report a piezoelectric nanostickers that activate voltage-gated calcium channels (VGCC) on the surface of neural stem cells under ultrasound, inducing calcium ion influx.The influx of calcium ions leads to the upregulation of CaMKⅡ expression and phosphorylation, which initiates downstream signal transduction pathways in the process of neurogenesis. Phosphorylated CaMKⅡ (P-CaMKⅡ) enters the nucleus, where it facilities the phosphorylation of CREB. The phosphorylation of CREB enhances the expression of target gene, BDNF, ultimately leading to the completion of neurogenesis.

2025-01-13 | GSE285483 | GEO

Transcriptomic response of in vitro potato (Solanum tuberosum L.) to piezoelectric ultrasound

Project description:As part of a wider project to assess the impact of ultrasound on in vitro plant growth, this paper aimed to determine whether the application of piezoelectric ultrasound (PE-US) would induce changes to the transcriptome of in vitro potato (Solanum tuberosum L.). After exposing explants (single-node segments with a single leaf) to PE-US (35 kHz; 70 W) for 20 min, the effect of this stressor was determined at 0 h, 24 h, 48 h, 1 w and 4 w to assess the possible immediate and residual effects of PE-US on the potato transcriptome.

2020-03-03 | GSE135294 | GEO

Transcriptomic response of in vitro potato (Solanum tuberosum L.) to piezoelectric ultrasound

Project description:Transcriptomic response of in vitro potato (Solanum tuberosum L.) to piezoelectric ultrasound

| PRJNA558262 | ENA

Gene expression profiles after traumatic brain injury

Project description:Time dependent-profiles in the gene expression level following lateral moderate fluid percussion injury in the rat brain We used microarray to elucidate relationship between the alteration of gene expression levels and the progression of brain damages following traumatic brain injury. To examine the levels of gene expression in the early phase of traumatic brain injury, we analyzed the gene expression at 3, 6, 12, and 48 h after trauma using the lateral moderate fluid percussion TBI model. The ratios of the gene expression level were compared between chips corresponding to the 3, 6 and 12 h fluid percussion groups and the sham group chips. On the other hand, the rations of gene expression level after 48 h FPI were compared with 48 h sham chip, because the gene expression levels of 48 h sham chip were distinct from sham group chips (3, 6 and 12 h) in the cluster and principal components analyses.

2010-12-07 | E-GEOD-24047 | biostudies-arrayexpress

The dentate gyrus after traumatic brain injury [miRNA]

Project description:Analysis of the dentate gyrus of traumatic brain injury model. Results provide insight into the molecular mechanism underlying TBI.

2017-02-25 | GSE86614 | GEO

The dentate gyrus after traumatic brain injury [mRNA]

Project description:Analysis of the dentate gyrus of traumatic brain injury model. Results provide insight into the molecular mechanism underlying TBI.

2017-02-25 | GSE86579 | GEO

Gene expression profiles after traumatic brain injury

2010-12-07 | GSE24047 | GEO

Phosphoproteomic Response of Cardiac Endothelial Cells to Ischemic Injury and Ultrasound

Project description:Global and phosphoproteomic data from mouse primary cardiac endothelial cells treated with oxygen deprivation and/or ultrasound. Samples were digested with trypsin, then analyzed by LC-MS/MS. Data was searched with MS-GF+ using PNNL's DMS processing pipeline.

2020-12-31 | MSV000086652 | MassIVE

Comprehensive analysis of circRNA expression profiles in rat cerebral cortex after moderate traumatic brain injury

Project description:Background: Traumatic brain injury is a medical event of global concern, and a growing body of research suggests that circular RNA can play very important roles in traumatic brain injury. To explore the functions of more novel and valuable circular RNA in traumatic brain injury response, a moderate traumatic brain injury in rat was established and a comprehensive analysis of circular RNA expression profiles in rat cerebral cortex was done. Results: As a result, 301 up-regulated and 284 down-regulated circular RNAs were obtained in moderate traumatic brain injury rats, the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were performed based on the circular RNA’s host genes, and a circRNA-miRNA interaction network based on differentially expressed circular RNAs was constructed. Also, four circular RNAs were validated by RT-qPCR and sanger sequencing. Conclusion: This study showed that differentially expressed circular RNAs existed between rat cerebral cortex after moderate traumatic brain injury and control. And this will provide valuable information for circular RNA research in the field of traumatic brain injury.

2022-01-15 | GSE193521 | GEO

Chronic Gene Expression after Traumatic Brain Injury

Project description:This project continues our acute TBI studies and initiates chronic studies -- characterizing the temporal genomic profile of the injured brain up to 12 months post-TBI. Thus, the primary objective of this proposal is to determine the long-term effects of traumatic brain injury on gene expression in the hippocampus and cortex, two brain regions known to be particularly vulnerable to TBI.

2018-09-01 | GSE111452 | GEO

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