Project description:This study is to compare the mRNA expression differences between atherosclerosis and non-atherosclerosis samples from female peripheral blood. The possible effects of races are also considered.
Project description:Genome-wide DNA methylation screening was performed using the Infinium HumanMethylation450 BeadChip in 34 samples of non-cancerous pancreatic tissue and 82 samples of cancerous tissue samples obtained from 82 patients with pancreatic ductal adenocarcinoma.
Project description:Atherosclerosis is fundamental in the development of cardiovascular disease. The unhealthy dietary habits, high fat and cholesterol intake could change the composition of gut microbes and metabolites which play a critical role in the development of atherosclerosis. To characterize the functionality of intestinal microbiome in the AS, we performed an analysis of microbiota proteins by a metaproteomics technique in 6 control samples and 6 feces samples. Using data dependent acquisition (DDA), a total of 8467 peptides with taxonomy annotation were identified and which were correspond to 3851 protein groups.
Project description:Eighteen samples were obtained from 9 patients who underwent delayed resection. The purpose of this study is to identify transcriptomic shifts in samples during therapy.
Project description:The microarray gene expression profiles of human carotids with advanced atherosclerosis obtained at autopsy (n=4) were compared with those obained at vascular surgery (n=3).
Project description:To examine mononuclear cell gene expression profiles in patients with and without SLE and subsets with and without atherosclerosis Monocytes were obtained from 20 patients with SLE and 16 healthy controls and were in vitro differentiated into macrophages. Subjects also underwent laboratory and imaging studies of the coronary arteries, carotid arteries, and aorta to evaluate for subclinical atherosclerosis.