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Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice

ABSTRACT: Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice

PROVIDER: PRJNA1208476 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31941846_1.fastq.gz	Fastqsanger.gz
	SRR31941846_2.fastq.gz	Fastqsanger.gz
	SRR31941847_1.fastq.gz	Fastqsanger.gz
	SRR31941847_2.fastq.gz	Fastqsanger.gz
	SRR31941848_1.fastq.gz	Fastqsanger.gz

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Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice

Project description:Anti-programmed death 1 (αPD1) immune checkpoint blockade is used in combination for cancer treatment but associated with cardiovascular toxicity. Finding drugs that suppress cardiovascular toxicity but not compromise the efficacy of αPD1-mediated immunotherapy is of great importance. Leflunomide (Lef) can suppress the growth of several tumor and mitigate cardiac remodeling in mice. However, the specific role of Lef in αPD1-induced cardiotoxicity remains unclear.

2025-02-01 | GSE286252 | GEO

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Project description:Recently, gut metabolites have been recognized to play significant roles in liver diseases via the gut-liver axis. In this study, we investigate the regulatory effects of the tryptophan metabolite, indole-3-propionic acid (IPA), on immune cells during liver fibrogenesis using single-cell RNA sequencing (scRNA-seq).

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RNA sequencing of L4-L6 mouse Dorsal Root Ganglia 3 days post sciatic nerve crush and naive following 10 days of Indole-3-propionic acid treatment

Project description:Purpose: compare the response of DRG neurons to indole-3-propionic acid treatment before and after sciatic nerve injury Results: we found that IPA induced transcription changes before and after injury inside the DRG tissue. In particular expression of immune system related genes

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mRNA-seq analysis of HCT116 cells following gene overexpression of IDO1 with or without Indole treatment

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Project description:Enhanced growth and productivity of useful metabolites by indole-3-propionic acid treatment in Lemna aequinoctialis culture

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Gut-derived indole propionic acid alleviates liver fibrosis by modulating pro-fibrogenic macrophage phenotype and biological function

Project description:Gut-derived indole propionic acid alleviates liver fibrosis by modulating pro-fibrogenic macrophage phenotype and biological function

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mRNA-seq analysis of HCT116 cells following gene overexpression of IDO1 with or without Indole treatment

Project description:To investigate the effect of indole on protection against colon injury and the role of IDO1 expression, we examined the effect of indole on hIDO1-overexpressing and empty vector control HCT116 cells by global gene expression profiling. Examination of mRNA levels from hIDO1-overexpressing and control HCT116 cell lines treated with 1mM indole or DMF for 24 hours using two replicates each.

2016-07-01 | E-GEOD-83939 | biostudies-arrayexpress

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Project description:Kentucky assay: Indole

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Salmonella wild type in LB, 2mM indole until OD1 and 2mM indole for 15 minutes

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2013-01-30 | GSE39760 | GEO

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