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Saccharomyces bayanus x Saccharomyces cerevisiae

ABSTRACT: Polygenic and directional regulatory evolution across pathways in Saccharomyces

PROVIDER: PRJNA122057 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR035884.fastq.gz	Fastqsanger.gz
	SRR035885.fastq.gz	Fastqsanger.gz
	SRR035886.fastq.gz	Fastqsanger.gz
	SRR035887.fastq.gz	Fastqsanger.gz
	SRR035888.fastq.gz	Fastqsanger.gz

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Polygenic and directional regulatory evolution across pathways in Saccharomyces

Project description:We assess the prevalence of polygenic evolution in pathways between the yeasts S. cerevisiae and S. bayanus. We first established short-read sequencing methods to detect cis-regulatory variation in a diploid hybrid between the species. We then formulated an analytic strategy to test for the scenario in which selective pressure in one species, to increase or decrease the activity of a pathway, has driven the accumulation of cis-regulatory variants that act in the same direction on gene expression. Application of this test revealed a variety of yeast pathways with evidence for directional regulatory evolution. Measurement of allele-specific expression of each ortholog in a diploid hybrid between Saccharomyces species

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