Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene regulatory consequecnes of loss of Kdm1a in the kidney [RRBS]

ABSTRACT: Gene regulatory consequecnes of loss of Kdm1a in the kidney [RRBS]

PROVIDER: PRJNA1227539 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32472936_1.fastq.gz	Fastqsanger.gz
	SRR32472936_2.fastq.gz	Fastqsanger.gz
	SRR32472937_1.fastq.gz	Fastqsanger.gz
	SRR32472937_2.fastq.gz	Fastqsanger.gz
	SRR32472938_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Gene regulatory consequecnes of loss of Kdm1a in the kidney [RRBS]

Project description:Histone methyltransferases and demethylases play crucial roles in gene regulation and are vital for the proper functioning of multiple tissues. In this study, we investigated the functions of Kdm1a by employing a renal progenitor-specific deletion during kidney development and evaluated global differences in DNA methylation between control and Kdm1a conditional knockout kidneys using Reduced representation bisulfite sequencing (RRBS-seq).

2025-02-28 | GSE290356 | GEO

Gene regulatory consequecnes of loss of Kdm1a in the kidney [RNA-Seq]

Project description:Gene regulatory consequecnes of loss of Kdm1a in the kidney [RNA-Seq]

| PRJNA1224255 | ENA

Gene regulatory consequecnes of loss of Kdm1a in the kidney [ChIP-Seq]

Project description:Gene regulatory consequecnes of loss of Kdm1a in the kidney [ChIP-Seq]

| PRJNA1224252 | ENA

Gene regulatory consequecnes of loss of Kdm1a in the kidney [RNA-Seq]

Project description:Histone methyltransferases and demethylases play crucial roles in gene regulation and are vital for the proper functioning of multiple tissues. In this study, we investigated the functions of Kdm1a by employing a renal progenitor-specific deletion during kidney development and evaluated global differences in gene expression between control and Kdm1a conditional knockout kidneys using RNA sequencing (RNA-seq).

2025-02-28 | GSE289720 | GEO

Gene regulatory consequecnes of loss of Kdm1a in the kidney [ChIP-Seq]

Project description:Histone methyltransferases and demethylases play crucial roles in gene regulation and are vital for the proper functioning of multiple tissues. In this study, we investigated the functions of Kdm1a by employing a renal progenitor-specific deletion during kidney development and evaluated global differences in H3K9 trimethylation between control and Kdm1a conditional knockout kidneys using Chromatin Immunoprecipitation DNA sequencing (ChIP-seq).

2025-02-28 | GSE289719 | GEO

The epigenetic regulatory role of KDM1A in HCC cells

Project description:We performed CUT&Tag-seq to explore the epigenetic regulatory roles of KDM1A in HCC cells.

2024-05-31 | GSE255636 | GEO

Revealing regulatory transcription factors of aging in the kidney and kidney through multi-omics analysis

Project description:Aging is accompanied by a gradual loss of systemic metabolic homeostasis, which is maintained by multiple-organs, especially the kidney and kidney. However, a systematic study of the regulatory networks and regulatory transcription factors (TFs) of aging in the kidney and kidney remains lacking. Here, we performed an integrated analysis of multi-omics datasets in the kidney and kidney from young and aged mice, including RNA-seq, reduced representation bisulfite sequencing (RRBS) and ATAC-seq datasets, which indicated that enhanced inflammation and dysregulated metabolism were conserved signatures in aged kidney and kidney in both the transcriptome and epigenome. Transcription factor and regulatory network analysis indicated that activation of AP-1 and SPI1 was responsible for enhanced inflammation, and down-regulation of HNFs and PPARs contributed to dysregulated metabolism in aged kidney and kidney. Importantly, we found that the activation of AP-1 was cellular autonomous in aged hepatic and renal cells. However, enhanced SPI1 was caused by elevated infiltration of macrophages. Importantly, inhibition of AP-1 with small molecule combination attenuated inflammation phenotypes of aging in vivo and in vitro. Taken together, our analysis revealed common signatures and regulatory TFs of aging in the kidney and kidney, providing novel targets for the development of anti-aging interventions.

2021-10-01 | GSE181797 | GEO

The epigenetic regulatory role of KDM1A in HCC cells [HepG2_shKDM1A_CUTTag_seq]

Project description:We performed CUT&Tag-seq to explore the epigenetic regulatory roles of KDM1A in HCC cells.

2024-05-31 | GSE228074 | GEO

Loss of 9p21 regulatory hub promotes kidney cancer progression by upregulating HOXB13

Project description:Loss of 9p21 regulatory hub promotes kidney cancer progression by upregulating HOXB13

| PRJNA559845 | ENA

The epigenetic regulatory role of KDM1A in HCC cells

Project description:The epigenetic regulatory role of KDM1A in HCC cells

| PRJNA1075808 | ENA