Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq analysis of concentration-response transcriptomic changes induced by cannabinol (CBN) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

ABSTRACT: RNA-seq analysis of concentration-response transcriptomic changes induced by cannabinol (CBN) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

PROVIDER: PRJNA1238241 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32769918_1.fastq.gz	Fastqsanger.gz
	SRR32769918_2.fastq.gz	Fastqsanger.gz
	SRR32769919_1.fastq.gz	Fastqsanger.gz
	SRR32769919_2.fastq.gz	Fastqsanger.gz
	SRR32769920_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

Concentration-response transcriptomic changes induced by silver nanoparticles (AgNPs) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

Project description:Concentration-response transcriptomic changes induced by silver nanoparticles (AgNPs) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

| PRJNA1081393 | ENA

RNA-seq analysis of concentration-response transcriptomic changes induced by cannabinol (CBN) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

Project description:Currently little is known about the safety of nonintoxicating cannabinoids such as cannabinol (CBN). New approach methodologies (NAMs) based on bioinformatic analysis of high-throughput transcriptomic data are gaining increasing importance in risk assessment and regulatory decision-making of data-poor chemicals. In this study, we conducted a concentration response transcriptomic analysis of CBN in hepatocytes derived from human induced pluripotent stem cells (iPSCs). Biological functions and pathways impacted by CBN exposure were identified, including liver metabolism and cellular oxidative stress. In addition, a transcriptomic point-of-departure (tPoD) value was determined for CBN through benchmark concentration (BMC) analysis of the transcriptomic data. The present study demonstrates the potential utility of transcriptomic BMC analysis as a NAM for hazard assessment of data-poor chemicals, improves our understanding of the possible health effects of CBN, and provides important tPoD data that could contribute to inform human safety assessment of cannabinoid compounds.

2025-03-24 | GSE292356 | GEO

RNA-seq analysis of concentration-response transcriptomic changes induced by cannabichromene (CBC) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

Project description:Currently little is known about the safety of nonintoxicating cannabinoids such as cannabichromene (CBC). New approach methodologies (NAMs) based on bioinformatic analysis of high-throughput transcriptomic data are gaining increasing importance in risk assessment and regulatory decision-making of data-poor chemicals. In this study, we conducted a concentration response transcriptomic analysis of CBC in hepatocytes derived from human induced pluripotent stem cells (iPSCs). Biological functions and pathways impacted by CBC exposure were identified, including liver metabolism and cellular oxidative stress. In addition, a transcriptomic point-of-departure (tPoD) value was determined for CBC through benchmark concentration (BMC) analysis of the transcriptomic data. The present study demonstrates the potential utility of transcriptomic BMC analysis as a NAM for hazard assessment of data-poor chemicals, improves our understanding of the possible health effects of CBC, and provides important tPoD data that could contribute to inform human safety assessment of cannabinoid compounds.

2025-03-24 | GSE292355 | GEO

Microarray analysis of concentration-response transcriptomic changes induced by cannabinol (CBN) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

Project description:Microarray analysis of concentration-response transcriptomic changes induced by cannabinol (CBN) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

| PRJNA1235823 | ENA

Microarray analysis of concentration-response transcriptomic changes induced by cannabichromene (CBC) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

Project description:Microarray analysis of concentration-response transcriptomic changes induced by cannabichromene (CBC) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

| PRJNA1235824 | ENA

RNA-seq analysis of concentration-response transcriptomic changes induced by cannabichromene (CBC) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

Project description:RNA-seq analysis of concentration-response transcriptomic changes induced by cannabichromene (CBC) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

| PRJNA1238242 | ENA

Transcriptome of bovine induced pluripotent cells (iPSCs)

Project description:Transcriptome of bovine induced pluripotent cells (iPSCs)

| PRJNA717233 | ENA

Concentration-response transcriptomic changes induced by silver nanoparticles (AgNPs) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

Project description:Transcriptomic changes in iPSC-derived hepatocytes after exposure to varying concentrations of AgNPs (0.01-25 μg/ml) for 24 h.

2024-06-21 | GSE259384 | GEO

Microarray analysis of concentration-response transcriptomic changes induced by cannabichromene (CBC) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

Project description:Transcriptomic changes measured by microarray in iPSC-derived hepatocytes after exposure to varying concentrations of CBC (0.1-40 μM) for 24 h.

2025-03-21 | GSE291936 | GEO

Microarray analysis of concentration-response transcriptomic changes induced by cannabinol (CBN) in hepatocytes derived from human induced pluripotent stem cells (iPSCs)

Project description:Transcriptomic changes measured by microarray in iPSC-derived hepatocytes after exposure to varying concentrations of CBN (0.1-20 μM) for 24 h.

2025-03-21 | GSE291937 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data