Project description:The incidence of breast cancer has been rapidly increasing in East Asia. This is the first study of genome wide copy number of breast cancer in East Asia. We conducted this study to compare the genetic alterations between East and West.
Project description:Affymetrix single nucleotide polymorphism (SNP) array data were collected to study genome-wide patterns of genomic variation across a broad geographical range of Island Southeast Asian populations. This region has experienced an extremely complex admixture history. Initially settled ~50,000 years ago, Island Southeast Asia has since been the recipient of multiple waves of population movements, most recently by Austronesian-speaking groups ultimately from Neolithic mainland Asia and later arrivals during the historic era from India and the Middle East. We have genotyped SNPs in ~500 individuals from 30 populations spanning this entire geographical region, from communities close to mainland Asia through to New Guinea. Particular attention has been paid to genomic data that are informative for population history, including the role of recent arrivals during the historic era and admixture with archaic hominins.
Project description:We compared the transcriptional profiles of female adult whiteflies of B. tabaci Middle East-Asia Minor 1 feeding on TYLCCNV-free and TYLCCNV-infected tobacco plants using the next-generation sequencing technique.
Project description:Myanmar locates in the crossroads of South Asia, Southeast Asia, and East Asia, and is known for high culture diversity in different ethnic groups. It is considered to be important for understanding human evolutionary history and genetic diversity in East Eurasia. However, relatively few studies have examined the population structure and demographic history in Myanmar to date. In this study, we analyzed more than 220,000 genome-wide SNPs in 175 new samples of five ethnic groups from Myanmar and compared them with the published data. Our results showed that the Myanmar population is intricately substructured, with the main observed clusters corresponding roughly to western/northern highlanders (Chin, Naga, and Jingpo) and central/southern lowlanders (Bamar and Rakhine). The gene flow inferred from South Asia has a substantial influence (~11%) on the gene pool of central/southern lowlanders rather than western/northern highlanders. The genetic admixture is dated around 650 years ago. These findings suggest that the genome-wide variation in Myanmar was likely shaped by the linguistic, cultural, and historical changes.
Project description:The whitefly Bemisa tabaci is a species complex with global distribution and extensive genetic diversity. In this species complex, Middle East-Asia Minor 1 (MEAM1, previously referred to as the âB biotypeâ) species has been spreading rapidly in tropical and subtropical regions. we analyzed the transcriptional responses of the invasive MEAM1 and the indigenous Asia II 3 species of B. tabaci complex during host plant shift (from cotton to tobacco) using the Illumina sequencing technology.The different gene expression pattern of energy and carbonhydrate metabolism and detoxification metabolism between MEAM1 and Asia II 3 were the main reasons of their different capacity of adapation. The global transcriptional difference between the invasive whitefly Bemisia tabaci species (MEAM1) and the indigenous whitefly species (Asia II 3) on cotton and tobacco were analyzed using the Illumina sequencing technology.
Project description:The whitefly Bemisa tabaci is a species complex with global distribution and extensive genetic diversity. In this species complex, Middle East-Asia Minor 1 (MEAM1, previously referred to as the ‘B biotype’) species has been spreading rapidly in tropical and subtropical regions. we analyzed the transcriptional responses of the invasive MEAM1 and the indigenous Asia II 3 species of B. tabaci complex during host plant shift (from cotton to tobacco) using the Illumina sequencing technology.The different gene expression pattern of energy and carbonhydrate metabolism and detoxification metabolism between MEAM1 and Asia II 3 were the main reasons of their different capacity of adapation.
Project description:Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and South East Asia where more than 50,000 new cases are diagnosed each year. We used microarrays to identify down or upregulated genes in NPC compared with non-malignant controls. Keywords: Diseased versus control
Project description:We analyzed the global defense responses in common tobacco against a begomovirus Tomato yellow leaf curl China virus, an invasive whitefly species Middle East-Asia Minor 1, and their co-infestation. The transcripts of defense related genes were both overlapping and divergent in response to virus and whitefly.
Project description:The whitefly Bemisa tabaci is a species complex of more than 31 cryptic species which include some of the most destructive invasive pests of many ornamental and glasshouse crops worldwide. Among them, Middle East-Asia Minor 1 (herein MEAM1) and Mediterranean (herein MED) have invaded many countries around the world and displaced the native whitefly species. However, the molecular differences between invasive and indigenous whiteflies remain largely unknown. The global transcriptional difference between the two invasive whitefly Bemisia tabaci species (MEAM1, MED) and one indigenous whitefly species (Asia II 3) were analyzed using the Illumina sequencing technology.
