Schistosoma haematobium
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA12616 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Other | ||||
| SRR12390671_1.fastq.gz | Fastqsanger.gz | |||
| SRR15400745_1.fastq.gz | Fastqsanger.gz | |||
| SRR15400745_2.fastq.gz | Fastqsanger.gz | |||
| SRR15400746_1.fastq.gz | Fastqsanger.gz |
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Project description:Schistosoma haematobium population exomics
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Project description:Urogenital schistosomiasis (caused by Schistosoma haematobium) remains a major public health concern worldwide. In response to parasite egg deposition, the host bladder undergoes gross and molecular morphological changes relevant for disease manifestation. However, limited mechanistic studies to date imply that the molecular mechanisms underlying pathology have not been well-defined. We leveraged a mouse model of urogenital schistosomiasis to perform for the first time, proteome profiling of the early molecular events that occur in the bladder after exposure to S. haematobium eggs, and to elucidate the protein pathways involved in urogenital schistosomiasis-induced pathology. Purified S. haematobium eggs or control vehicle were microinjected into the bladder walls of mice. Mice were sacrificed seven days post-injection and bladder proteins isolated and processed for proteome profiling using mass spectrometry.
2022-01-23 | PXD029852 | Pride
Project description:Schistosoma haematobium Genome sequencing and assembly
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Project description:A pilot EST project for Schistosoma haematobium has begun
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Project description:Despite the clear role of adult secreted and tegumental proteins as well as egg proteins in host-parasite interactions, there has not been any in-depth proteomic analysis of these or other Schistosoma haematobium proteomes. In the current project we have carried out the first comprehensive proteomic analysis of S. haematobium. The characterisation of the molecules playing a key role at the interphase between the host and the parasite is crucial for (i) a better understanding of the parasite’s biology and, (ii) for the development of new control and diagnostic approaches to tackle parasitic infections.
2019-04-09 | PXD011137 | Pride
Project description:Schistosome worms infect over 200 million people worldwide. They live in the host’s bloodstream and alter host immunity. Epidemiological data suggest that males and females have different responses to schistosome infection, but the effect of sex on systemic response is undetermined. Our objective was to characterize differences in peripheral blood transcriptional profiles in people with or without active Schistosoma haematobium infection and to determine whether this signature differs between males and females. mRNA was isolated using poly(A) selection and sequenced on an Illumina Hi-Seq4000 platform. Transcripts were aligned to the human hg19 reference genome and counted with the HTSeq package. Genes were compared for differential expression using DESeq2. Ingenuity Pathway Analysis (IPA) was used to identify gene networks altered in the presence of S. haematobium. We enrolled 33 participants from villages in rural Tanzania where S. haematobium is endemic. After correction for multiple comparisons, we observed 383 differentially expressed genes between those with or without S. haematobium infection when sex was included as a covariate. Heat-mapping of the genes with 1.5-fold differences in gene expression revealed clustering by S. haematobium infection status. The top networks included development, cell death and survival, cell signaling, and immunologic disease pathways. We observed a distinct whole blood transcriptional profile, as well as differences in men and women, with S. haematobium infection. Additional studies are needed to determine the clinical effects of these divergent responses. Attention to sex-based differences should be included in studies of schistosome infection.
2020-01-25 | GSE144206 | GEO
Project description:Background: Schistosomiasis is a major public health challenge and one of the neglected tropical diseases globally. Schistosoma haematobium, the causative agent of urogenital schistosomiasis, is primarily endemic in African countries, with school-aged children (7 to 15 years) considered the most vulnerable population. The current diagnostic method relies on identifying parasite eggs in urine through microscopy, which is labor-intensive, requires specialized skills, and is often limited in sensitivity, especially in mild infections. Disease-related biomarkers offer a promising avenue for advancing disease diagnosis and detection. Method: A total of 135 school-aged children (aged 7—15 years) from Zanzibar were recruited for this study. To identify potential host protein biomarkers, data independent acquisition (DIA) proteomics combined with machine learning was used to screen for differentially expressed proteins in the urine samples from individuals infected with schistosome haematobium. Machine learning was used to pinpoint the most discriminative proteins, which were subsequently validated using enzyme-linked immunosorbent assay (ELISA). Results: Proteomic analysis identified 823 common host proteins in urine samples from the infection group, with 269 proteins showing significant differential expression. Of these, 149 were up-regulated and 120 were down-regulated in the infected group. Machine learning further highlighted SYNPO2, CD276, α2M, LCAT, and hnRNPM as the most discriminating biomarkers for Schistosomiasis haematobium infection. ELISA validation confirmed the differential expression trends of these proteins, underscoring their diagnostic potential. Conclusions: This study identified key urinary protein biomarkers associated with Schistosoma haematobium
2025-06-16 | PXD059942 | Pride
Project description:Blood flukes of the genus Schistosoma (Platyhelminthes, Trematoda, Digenea) are responsible for the chronic debilitating disease schistosomiasis / bilharzia, widely considered to be second only to malaria as a global health problem and an incalculable drain on the economic development of endemic countries. Since 1994, the World Health Organization has supported a genome initiative for Schistosoma, the Schistosoma Genome Network, aimed at identifying new targets for drug and vaccine development, understanding the molecular basis of parasite metabolism and development and determining biological variation. The study of small-RNAs as key players in the regulation of gene expression differentiation is important to the understanding of the parasites biology. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
2013-05-28 | E-ERAD-93 | biostudies-arrayexpress