Project description:H3R17 methylation inhibitor TBBD associated differential gene expression in embryoid bodies was assessed by microarray analysis treated with 10uM TBBD for 48 hours compared to DMSO control treated Ebs Affymetrix one-color experiment,Organism: Homo sapiens[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array
Project description:This SuperSeries is composed of the following subset Series: GSE26018: Crosstalk between gene body DNA methylation, H3K9me3 and H3K36me3 chromatin marks and transcription [HuEx-1_0-st] GSE26019: Crosstalk between gene body DNA methylation, H3K9me3 and H3K36me3 chromatin marks and transcription [HuGene-1_0-st] GSE26038: Crosstalk between gene body DNA methylation, H3K9me3 and H3K36me3 chromatin marks and transcription [HuEx-1_0-st, transcript] GSE26040: Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks Refer to individual Series
Project description:Human synovial biopsies were collected from normal and osteoarthritic joints. CD90 positive cells were isolated and confirmed to have multipotent differentiation capacity. An n=2 of normal and n=2 OA lines were run on the HuGene-1_0-st-v1 array.
Project description:Chronic infection of M. hyorhinis is postulated to be associated with cancer cell migration and invasion. To explore the mechanisms of M. hyorhinis-promoted invasiveness, we performed Affymetrix genechip (HuGene-1_0-st) analysis to examine differential gene expression profiles between non-infected and infected gastric cancer cells. We used microarrays to detail global programme of gene expression and identified distinct classes of upregulated genes after M. hyorhinis infection of gastric cancer cell lines.
Project description:Human pluripotent stem cells were differentiated into hematopoietic progenitors, which were then re-specified using defined transcription factors to resemble hematopoietic stem cells (HSC) We used microarrays to establish the similarity between converted cells and purified human HSCs. The samples analyzed were: starting embryoid body progenitors, transcription factor-converted cells, and primary HSCs and progenitors from fetal liver and cord blood. All samples were flow sorted for CD34+ and CD38- to compare across a similar population of primitive cells.
Project description:This study identified DNA methylation patterns that were associated with tumor subtypes, disease outcome, and distinct metabolome and gene expression patterns. This study performed a large scale DNA methylation (Illumina HumanMethylation450 BeadChip [HumanMethylation450 15017482 v.1.1], N=73), gene expression (Affymetrix Human Gene 1.0 ST Array [HuGene-1_0-st], N=108), and metabolome (Metabolon, Inc. Durham, NC) analysis of fresh-frozen human breast tumors from African-American and European-American patients from the greater Baltimore area, Maryland (US), with survival follow-up.
Project description:This study identified DNA methylation patterns that were associated with tumor subtypes, disease outcome, and distinct metabolome and gene expression patterns. This study performed a large scale DNA methylation (Illumina HumanMethylation450 BeadChip [HumanMethylation450 15017482 v.1.1], N=72), gene expression (Affymetrix Human Gene 1.0 ST Array [HuGene-1_0-st], N=108), and metabolome (Metabolon, Inc. Durham, NC) analysis of fresh-frozen human breast tumors from African-American and European-American patients from the greater Baltimore area, Maryland (US), with survival follow-up.
