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ABSTRACT: Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium

OTHER RELATED OMICS DATASETS IN: GSE26141

PROVIDER: PRJNA135389 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR088641.fastq.gz	Fastqsanger.gz
	SRR088642.fastq.gz	Fastqsanger.gz
	SRR088643.fastq.gz	Fastqsanger.gz
	SRR088644.fastq.gz	Fastqsanger.gz
	SRR088645.fastq.gz	Fastqsanger.gz

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Project description:Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium [MSDK-Seq]

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Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium [MSDK-Seq]

Project description:Here we describe the application of high-throughput sequencing technology for profiling histone and DNA methylation, and gene expression patterns of normal human mammary progenitor-enriched and luminal lineage-committed cells. We observed significant differences in histone H3 lysine 27 tri-methylation (H3K27me3) enrichment and DNA methylation of genes expressed in a cell type-specific manner, suggesting their regulation by epigenetic mechanisms and a dynamic interplay between the two processes that together define developmental potential. The technologies we developed and the epigenetically regulated genes we identified will accelerate the characterization of primary cell epigenomes and the dissection of human mammary epithelial lineage-commitment and luminal differentiation. Global profiling of differentially methylated regions in 2 cell types from 6 individuals.

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Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium [SAGE-Seq]

Project description:Here we describe the application of high-throughput sequencing technology for profiling histone and DNA methylation, and gene expression patterns of normal human mammary progenitor-enriched and luminal lineage-committed cells. We observed significant differences in histone H3 lysine 27 tri-methylation (H3K27me3) enrichment and DNA methylation of genes expressed in a cell type-specific manner, suggesting their regulation by epigenetic mechanisms and a dynamic interplay between the two processes that together define developmental potential. The technologies we developed and the epigenetically regulated genes we identified will accelerate the characterization of primary cell epigenomes and the dissection of human mammary epithelial lineage-commitment and luminal differentiation. Global transcriptome profilings of 15 samples in normal breast tissue using Sage-Seq.

2011-03-01 | E-GEOD-26140 | biostudies-arrayexpress

Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium [SAGE-Seq]

2011-03-01 | GSE26140 | GEO

Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium [MSDK-Seq]

2011-03-01 | GSE26139 | GEO

Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium [ChIP-Seq]

2011-03-01 | GSE26137 | GEO

Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium [ChIP-Seq]

Project description:Here we describe the application of high-throughput sequencing technology for profiling histone and DNA methylation, and gene expression patterns of normal human mammary progenitor-enriched and luminal lineage-committed cells. We observed significant differences in histone H3 lysine 27 tri-methylation (H3K27me3) enrichment and DNA methylation of genes expressed in a cell type-specific manner, suggesting their regulation by epigenetic mechanisms and a dynamic interplay between the two processes that together define developmental potential. The technologies we developed and the epigenetically regulated genes we identified will accelerate the characterization of primary cell epigenomes and the dissection of human mammary epithelial lineage-commitment and luminal differentiation. Examination of histone H3K27me3 modifications in 2 cell types from 3 individuals and H3K4me3 modifications in 2 cell types from one individual sample.

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Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities

Project description:The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female. Perturbations of these lineages underpin breast cancer risk, yet our understanding of normal mammary cell composition is incomplete. Here, we build a multimodal resource for the adult gland through comprehensive profiling of primary cell epigenomes, transcriptomes, and proteomes. We define systems-level relationships between chromatin–DNA–RNA–protein states, identify lineage-specific DNA methylation of transcription factor binding sites, and pinpoint proteins underlying progesterone responsiveness. Comparative proteomics of estrogen and progesterone receptor–positive and –negative cell populations, extensive target validation, and drug testing lead to discovery of stem and progenitor cell vulnerabilities. Top epigenetic drugs exert cytostatic effects; prevent adult mammary cell expansion, clonogenicity, and mammopoiesis; and deplete stem cell frequency. Select drugs also abrogate human breast progenitor cell activity in normal and high-risk patient samples. This integrative computational and functional study provides fundamental insight into mammary lineage and stem cell biology. PMID: 29921600 (Table S5 and Table S7)

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