Sus scrofa
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA136405 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:While the salutary effects of exercise training on conduit artery endothelial cells have been reported in animals and humans with cardiovascular risk factors or disease, whether a healthy endothelium is alterable with exercise training is less certain. The purpose of this study was to evaluate the impact of exercise training on transcriptional profiles in normal endothelial cells using a genome-wide microarray analysis. Brachial and internal mammary endothelial gene expression was compared between a group of healthy pigs that exercise-trained for 16-20 weeks (n=8) and a group that remained sedentary (n=8). We found that a total of 130 genes were up regulated and 84 genes down regulated in brachial artery endothelial cells with exercise training. In contrast, a total of 113 genes were up regulated and 31 genes down regulated in internal mammary artery endothelial cells (>1.5-fold and false discovery rate<15%). Although there was an overlap of 66 genes (59 up regulated and 7 down regulated with exercise training) between the brachial and internal mammary arteries, the identified endothelial gene networks and biological processes influenced by exercise training were distinctly different between the brachial and internal mammary arteries. These data indicate that a healthy endothelium is indeed responsive to exercise training and support the concept that the influence of physical activity on endothelial gene expression is not homogenously distributed throughout the vasculature.
2011-12-02 | GSE26663 | GEO
Project description:While the salutary effects of exercise training on conduit artery endothelial cells have been reported in animals and humans with cardiovascular risk factors or disease, whether a healthy endothelium is alterable with exercise training is less certain. The purpose of this study was to evaluate the impact of exercise training on transcriptional profiles in normal endothelial cells using a genome-wide microarray analysis. Brachial and internal mammary endothelial gene expression was compared between a group of healthy pigs that exercise-trained for 16-20 weeks (n=8) and a group that remained sedentary (n=8). We found that a total of 130 genes were up regulated and 84 genes down regulated in brachial artery endothelial cells with exercise training. In contrast, a total of 113 genes were up regulated and 31 genes down regulated in internal mammary artery endothelial cells (>1.5-fold and false discovery rate<15%). Although there was an overlap of 66 genes (59 up regulated and 7 down regulated with exercise training) between the brachial and internal mammary arteries, the identified endothelial gene networks and biological processes influenced by exercise training were distinctly different between the brachial and internal mammary arteries. These data indicate that a healthy endothelium is indeed responsive to exercise training and support the concept that the influence of physical activity on endothelial gene expression is not homogenously distributed throughout the vasculature. Brachial and internal mammary endothelial gene expression was compared between a group of healthy pigs that exercise-trained for 16-20 weeks (n=8) and a group that remained sedentary (n=8). The arteries were taken from the same animals, and after quality assessment, so there were 29 total arrays (15 unique pigs), 14 with an array for both the brachial artery and the internal mammary artery (IMA), and the remaining 1 having only brachial. One pig had bad RNA quality and is missing from both IMA and brachical. Therefore, there were 15 IMA (7 SED, 8 EX) and 14 brachial arrays (7 SED, 7 EX) that were used in this study.
2011-12-02 | E-GEOD-26663 | biostudies-arrayexpress
Project description:This study investigates the regional expression profiles of microRNAs (miRNAs) in endothelial cells isolated from the athero-protective descending thoracic aorta (DT) and from the athero-susceptible aortic arch (AA) in a swine model. Seven 2-channel assays comparing DT samples to AA samples were performed using the Invitrogen NCode Multi-Species miRNA Microarray.
2010-07-16 | E-CBIL-46 | biostudies-arrayexpress
Project description:Subjects underwent endothelial testing and blood sampling at baseline and after 3 months of exercise training. Microarray and flow cytometry-based characterization of cells from an endothelial progeniator colony assay was consistent with T lymphocytes, but not endothelial cells. Experiment Overall Design: blood samples from 12 healthy subjects at baseline (A) and after 3 months (B) of exercise.
2009-01-13 | E-GEOD-12155 | biostudies-arrayexpress
Project description:Validation of the Swine Protein-Annotated Oligonucleotide Microarray.
| PRJNA109927 | ENA
Project description:MicroRNA transcriptome profiles during swine muscle development
| PRJNA302830 | ENA
Project description:Microarray gene expression profiling of 27k cDNAs in 23 healthy porcine tissues
| PRJNA95861 | ENA
Project description:In vivo endothelial transcriptional profiles of porcine coronary and iliac arteries
| PRJNA107249 | ENA
Project description:Subjects underwent endothelial testing and blood sampling at baseline and after 3 months of exercise training. Microarray and flow cytometry-based characterization of cells from an endothelial progeniator colony assay was consistent with T lymphocytes, but not endothelial cells. Keywords: expression analysis
2008-12-19 | GSE12155 | GEO
Project description:Endothelial transcriptional profiles of porcine coronary and iliac arteries passages 1 through 4
| PRJNA122375 | ENA