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Vibrio vulnificus YJ016

ABSTRACT: Opportunistic pathogen that affects immunocompromised patients, especially those with liver damage

PROVIDER: PRJNA1430 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR3569953.fastq.gz	Fastqsanger.gz
	SRR3582491.fastq.gz	Fastqsanger.gz
	SRR3582492.fastq.gz	Fastqsanger.gz
	SRR3582493.fastq.gz	Fastqsanger.gz

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Vibrio vulnificus CMCP6

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Iron regulation in Vibrio vulnificus CMCP6

2008-08-07 | GSE10633 | GEO

Vibrio vulnificus CMCP6 Proteome Analysis

Project description:Ribosomal proteins and global proteome were quantified by iTRAQ Labeling. Ribosomal proteins in 70S ribosomes purified from ΔrrnI-comp cells compared to those from ΔrrnI cells. Also, WT cells was measured.

2018-11-23 | PXD009215 | Pride

From environmental adaptation to virulence: OmpR plays an important role in Vibrio vulnificus

Project description:Vibrio vulnificus (V. vulnificus) is an opportunistic human pathogen known for causing various illnesses such as gastroenteritis, skin and muscle necrosis, septic shock, and sepsis. This halophilic estuarine bacterium's growth and infection process involves adaptation to both the natural briny environments and the host. OmpR, a response regulator in the EnvZ/OmpR two-component regulatory system (TCS), is crucial for environmental adaptation and pathogenicity. This study focused on investigating the impact of OmpR in V. vulnificus by creating an ompR knockout strain (ΔompR). The ΔompR strain exhibited reduced tolerance to alkaline stress, shorter flagella, and decreased virulence in epithelial cell and mouse models compared to the wild-type (WT) V. vulnificus. RNAseq analysis revealed the downregulation of genes involved in metabolism, flagellum-dependent motility, and transcription factors in the ΔompR strain. OmpR was found to repress the expression of aphB in alkaline conditions, impacting the acid resistance system CadBA, while also positively regulating the transcription of various flagellar genes. These findings suggest that OmpR acts as a global regulator, orchestrating the expression of multiple genes in response to different environments and during host invasion.

2024-11-08 | GSE281430 | GEO

European eel immune response against Vibrio vulnificus challenge

Project description:Vibriosis caused by Vibrio vulnificus on eels represents an important threat for this specie under culture conditions. Development of new transcriptomic tools is essential to increase the knowledge of eel biology, that nowadays is scarcer. Therefore, using previous results obtained by 454 sequencing of the eel immune-enriched transcriptome, an eel-specific custom microarray have been designed. Gills transcriptomic pattern were analyzed as a principal portal of entry for pathogens in fish after 1h of bath infection with Vibrio vulnificus to describe gill immune response. Moreover, two different strains were used, vibro vulnificus wild type (R99) and rtx double mutant (CT285), to asses the virulence of these pathogen caused by MARTX.

2013-03-15 | GSE45163 | GEO

Lipidomic characterization of Candida albicans in response to Aureobasidin treatment in vitro.

Project description:Candida albicans is an opportunistic yeast pathogen that causes a wide range of infections especially amongst immunocompromised patients. Aureobasidin A (AbA) has been shown to inhibit inositolphosphoryl ceramide synthase (IPCS), a key enzyme responsible for sphingolipid biosynthesis. There are limited studies exploring IPCS as a target molecule for antifungal treatment. It is hypothesized that the mechanism of AbA inhibition involves alteration of C. albicans phospholipid and sphingolipid profiles. The profiling of C. albicans phospholipid and sphingolipid upon exposure to 0.5-4 µg/ml of AbA were determined using Liquid chromatography-mass spectrometry (LC-MS).

2021-09-16 | ST001982 | MetabolomicsWorkbench

Iron regulation in Vibrio vulnificus CMCP6

Project description:Vibrio vulnificus multiply rapidly in host tissues under iron overloaded conditions. To understand the effects of iron in the physiology of this pathogen we performed a genome-wide transcriptional analysis of this bacterium growing under three different iron concentrations. V.vulnificus CMCP6 cells were grown under three different iron concentrations (TSBS + EDDA 50uM, TSBS and TSBS + FAC 250 ug/ml) and samples taken at log phase. Keywords: Response to the iron concentration of the media Strains were grown to an OD600nm of 0.6 to 0.8 in TSBS, TSBS with the addition of 250 Î¼g/ml FAC or TSBS with the addition of 50 Î¼M EDDA. Three independent cultures of the V. vulnificus cells grown in each media, were combined and treated as a single sample for the RNA extraction to minimize culture variation. Two samples per condition were used for the microarray analysis. Cells were centrifuged and the pellets resuspended in RNAWiz reagent (AmbionÂ®, Austin, TX). Total RNA was extracted from each strain according to the manufacturerâ??s instructions

2010-05-25 | E-GEOD-10633 | biostudies-arrayexpress

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