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Transcriptional landscape of the pathogenic yeast Candida parapsilosis

ABSTRACT: Transcriptional landscape of the pathogenic yeast Candida parapsilosis

PROVIDER: PRJNA146983 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR352253.fastq.gz	Fastqsanger.gz
	SRR352254.fastq.gz	Fastqsanger.gz
	SRR352255.fastq.gz	Fastqsanger.gz
	SRR352256.fastq.gz	Fastqsanger.gz
	SRR352257.fastq.gz	Fastqsanger.gz

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Transcriptional landscape of the pathogenic yeast Candida parapsilosis

Project description:This SuperSeries is composed of the following subset Series: GSE32712: Transcriptional profile of Candida parapsilosis CLIB214 21% Oxygen (normoxia) versus at 1% oxygen (hypoxia). GSE32713: Transcriptional profile of Candida parapsilosis CLIB214 versus UPC2 delete, both at 1% oxygen (hypoxia) GSE32714: Transcriptional landscape of Candida parapsilosis Refer to individual Series

2011-11-30 | E-GEOD-32716 | biostudies-arrayexpress

Centromere locations and structure in Candida parapsilosis.

Project description:Investigation of centromeres in the pathogenic yeast Candida parapsilosis, shows that the location of two centromeres are polymorphic within this species. The centromeres consist of large inverted repeats (IRs), surrounding unique sequences. New (neo) centromeres have emerged in one C. parapsilosis isolate even though the original CEN location is undamaged. The neocentromeres do not contain IRs, and have no obvious sequence features.

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Candida parapsilosis

Project description:Transcriptional landscape of Candida parapsilosis

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Interaction of soil amoeba Protostelium aurantium with three pathogenic yeasts Candida spp. (here: C. parapsilosis)

Project description:We investigated different escape and defense strategies of Candida parapsilosis against the natural fungivorous predator Protostelium aurantium using dual RNA-Seq. Trophozoites of the amoeba Protostelium aurantium were fed with C. parapsilosis and samples for RNA isolation were taken at time points 0 min (control), 30 min and 60 min. At indicated time points samples were shock frozen and used for RNA isolation. C. parapsilosis underwent rapid predation and intracellular killing of the yeast

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Project description:Candida parapsilosis WGS

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Transcriptional landscape of Candida parapsilosis cells assimilating hydroxyaromatic substrates

Project description:The pathogenic yeast Candida parapsilosis can utilize a wide range of hydroxyaromatic substrates as sole carbon sources through the 3-oxoadipate pathway (3-OAP) and the gentisate pathway (GP). It was previously established that the genes coding for the components of these pathways are arranged in two metabolic gene clusters. In this study we investigated the transcriptional regulation of these gene clusters, as well as the changes in major metabolic pathways in cells assimilating hydroxyaromates. First, using second and third generation sequencing technologies we determined the genomic sequence of the C. parapsilosis CLIB214 strain. This was then used as a platform to a transcriptomic and proteomic analysis of CLIB214 cells utilizing different substrates of the 3-OAP and the GP. Our results show that the activation of both pathways leads to upregulation of genes related to β-oxidation of fatty acids, glyoxylate cycle, metabolism of amino acids and the biogenesis of peroxisomes. In spite of the similar overall response, we identified quite the difference in gene expression between cells assimilating individual aromatic substrates and surprisingly, not only when comparing the substrates of the 3OAP with the GP substrates, but also between substrates channelled through the same pathway. Moreover, with the phenotype analysis of knockout mutants, we showed evidence that transcription factors Otf1 and Gtf1 function as transcriptional activators of genes coding for core components of the 3-OAP and GP, respectively.

2022-02-01 | PXD024608 | Pride

Candida parapsilosis

Project description:Candida parapsilosis Genome sequencing

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Transcriptional profile of Candida parapsilosis bcr1 knockout.

Project description:Whole genome microarrays were used to compare the transcriptional profile of Candida parapsilosis bcr1 knockout to wild type cells.

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Transcriptional analyses to decipher iron homeostasis in the pathogenic yeast Candida glabrata.

Project description:Microarray experiments were performed to reveal the key genes involved in iron homeostasis in the pathogenic yeast Candida glabrata.

2020-03-31 | GSE139363 | GEO

Candida parapsilosis

Project description:Candida parapsilosis Raw sequence reads

| PRJNA516045 | ENA