Gallus gallus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA152767 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Expression data from H2A.Z isoforms single KO cells
| PRJNA301232 | ENA
Project description:Expression data from WT, E2f8 KO, Rb KO and Rb;E2f8 DKO spleen Ter19+CD71high sorted cells
2014-07-30 | E-GEOD-52157 | ExpressionAtlas
Project description:The histone variant H2A.Z is evolutionarily conserved from yeast to vertebrates. H2A.Z regulates gene expression when localized to promoter region. Recently, we identified two genes encoding H2A.Z, H2A.Z-1 and H2A.Z-2 in vertebrate genome. However, it is not clear that both H2A.Z-1 and H2A.Z-2 were required for the function of H2A.Z in gene regulation. To address this issue, we generated the H2A.Z-1 and H2A.Z-2 double knock out (KO) cells in chicken DT40 cells. The expression pattern of H2A.Z-1 and H2A.Z-2 double KO cells was compared with WT cells to characterize the genes regulated by H2A.Z-1 and H2A.Z-2. We used microarrays to analysis the alternation of gene expression between WT and H2A.Z double KO cells and identify classes of up or down regulated gene by H2A.Z-1 and H2A.Z-2. In H2A.Z-1 and H2A.Z-2 double KO cells, H2A.Z-2 is knocked out constitutively, but H2A.Z-1 conditionally by tetracycline. The expression of H2A.Z-1 transgene is suppressed completely when H2A.Z-1 and H2A.Z-2 double KO cells culture with tetracycline for three days. For this reason, we prepared the total RNA of WT cells and H2A.Z-1and H2A.Z-2 double KO cells treated with tetracycline for three days and hybridization on Affymetrix microarrays.
2015-11-04 | E-GEOD-35430 | biostudies-arrayexpress
Project description:Expression data of mouse hematopoietic cells, Nr4a1/3 wild type and double mutant
2014-10-27 | E-GEOD-31042 | ExpressionAtlas
Project description:The histone variant H2A.Z is evolutionarily conserved from yeast to vertebrates. H2A.Z regulates gene expression when localized to promoter region. Recently, we identified two genes encoding H2A.Z, H2A.Z-1 and H2A.Z-2 in vertebrate genome. However, it is not clear that both H2A.Z-1 and H2A.Z-2 were required for the function of H2A.Z in gene regulation. To address this issue, we generated the H2A.Z-1 and H2A.Z-2 double knock out (KO) cells in chicken DT40 cells. The expression pattern of H2A.Z-1 and H2A.Z-2 double KO cells was compared with WT cells to characterize the genes regulated by H2A.Z-1 and H2A.Z-2. We used microarrays to analysis the alternation of gene expression between WT and H2A.Z double KO cells and identify classes of up or down regulated gene by H2A.Z-1 and H2A.Z-2.
2015-11-04 | GSE35430 | GEO
Project description:Gene Expression Data for male C57BL/6, Mdr2-KO and Mdr2-KO/IL6-KO at the age of 14 months
2015-07-08 | E-GEOD-37468 | ExpressionAtlas
Project description:Gene Expression Data for female C57BL/6, Mdr2-KO and Mdr2-KO/IL6-KO at the age of 14 months
2015-07-08 | E-GEOD-37559 | ExpressionAtlas
Project description:Gene expression from normal and Msi2 KO mouse LSK cells
2015-07-31 | E-GEOD-53385 | ExpressionAtlas
Project description:Expression data from embryonic stem cells differentiation
2015-08-04 | E-GEOD-58960 | ExpressionAtlas
Project description:Expression data of ALDH+ breast cancer cells
2025-01-24 | E-GEOD-52327 | ExpressionAtlas