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Homo sapiens

ABSTRACT: Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans (Bisulfite-Seq)

OTHER RELATED OMICS DATASETS IN: GSE38128

PROVIDER: PRJNA167305 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR499875_1.fastq.gz	Fastqsanger.gz
	SRR499875_2.fastq.gz	Fastqsanger.gz
	SRR499876_1.fastq.gz	Fastqsanger.gz
	SRR499876_2.fastq.gz	Fastqsanger.gz
	SRR499877_1.fastq.gz	Fastqsanger.gz

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Project description:Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans

| PRJNA167303 | ENA

Homo sapiens

Project description:Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans (Methylation BeadChip)

| PRJNA167304 | ENA

Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans (Methylation BeadChip)

Project description:A major concern in common disease epigenomics is distinguishing causal from consequential epigenetic variation. One means of addressing this issue is to identify the temporal origins of epigenetic variants via longitudinal analyses. However, prospective birth-cohort studies are expensive and time-consuming. Here we report DNA methylomics of archived Guthrie cards for the retrospective longitudinal analyses of in utero-derived DNA methylation variation. We first validate two methodologies for generating comprehensive DNA methylomes from Guthrie cards. Then, using an integrated epigenomic/genomic analysis of Guthrie cards and follow-up samplings, we identify inter-individual DNA methylation variation that is present both at birth and three years later. These findings suggest that disease-relevant epigenetic variation could be detected at birth i.e. before overt clinical disease. Guthrie card methylomics offers a potentially powerful and cost-effective strategy for studying the dynamics of inter-individual epigenomic variation in a range of common human diseases. Bisulphite converted DNA was hybridised to the Illumina Infinium 450k Human Methylation Beadchip

2012-08-27 | E-GEOD-37966 | biostudies-arrayexpress

Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans (Bisulfite-Seq)

2012-08-27 | E-GEOD-38127 | biostudies-arrayexpress

Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans (Methylation BeadChip)

2012-08-27 | GSE37966 | GEO

Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans (Bisulfite-Seq)

2012-08-27 | GSE38127 | GEO

The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates MYC as a Hypertrophic Regulator

Project description:Molecular control of recovery after exercise in muscle is temporally dynamic. A time course of biopsies around resistance exercise (RE) combined with -omics is necessary to better comprehend the molecular choreography of skeletal muscle adaptation in humans. We collected vastus lateralis biopsies before and 30 minutes, 3-, 8-, and 24 hours after acute RE. RNA-sequencing defined the transcriptome and a time-point matched biopsy only group were controls. DNA methylomics and computational approaches complimented the transcriptome data. Moreover, we tested whether cyclic transient overexpression of transcription factor MYC for 4 weeks were sufficient to induce skeletal muscle hypertrophy in female mice.

2024-04-17 | GSE252357 | GEO

Arabidopsis thaliana

Project description:Stable Inheritance of Spontaneous Epialleles in Arabidopsis thaliana

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Stable Inheritance of Spontaneous Epialleles in Arabidopsis thaliana

Project description:This research uses consecutive generations of two independent mutation accumulation (MA) lines in model organism A. thaliana to understand transgenerational stability of epialleles via self-fertilization. With whole-genome bisulfite sequencing, regions of instability were identified and quantified. The vast majority of the methylated genome is stably inherited to offspring and the identified unstable regions do not change frequently between generations. Additionally, an epigenetic cross of two MA lines was created to understand inheritance patterns of epialleles via outcrossing in the absence of genetic variation. Whole-genome bisulfite sequencing was used to predict epigenotype of the offspring without single nucleotide polymorphisms. In regions of differential methylation between the parents, about half of regions show predictable inheritance.

2017-07-24 | GSE94298 | GEO

Paramutation of natural epialleles in tomato [BiSulfite-seq]

Project description:Paramutation of natural epialleles in tomato [BiSulfite-seq]

| PRJNA380948 | ENA