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Plasmodium cynomolgi

ABSTRACT: An experimental model of malaria in monkeys

PROVIDER: PRJNA168002 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	DRR000469.fastq.gz	Fastqsanger.gz
	DRR000470.fastq.gz	Fastqsanger.gz
	DRR000471.fastq.gz	Fastqsanger.gz
	DRR000472.fastq.gz	Fastqsanger.gz

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Anopheles gambiae immune responses to human and rodent Plasmodium parasite species

Project description:Transmission of malaria is dependent on the successful completion of the Plasmodium lifecycle in the Anopheles vector. Major obstacles are encountered in the midgut tissue, where most parasites are killed by the mosquito’s immune system. In the present study, DNA microarray analyses have been used to compare Anopheles gambiae responses to invasion of the midgut epithelium by the ookinete stage of the human pathogen Plasmodium falciparum and the rodent experimental model pathogen P. berghei. Invasion by P. berghei had a more profound impact on the mosquito transcriptome, including a variety of functional gene classes, while P. falciparum elicited a broader immune response at the gene transcript level. Ingestion of human malaria-infected blood lacking invasive ookinetes also induced a variety of immune genes, including several anti-Plasmodium factors. Keywords: Anopheles gambiae, Plasmodium falciparum, ookinete, invasion, innate immunity

2007-08-15 | GSE8789 | GEO

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