Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Notechis scutatus

ABSTRACT: Notechis scutatus overview

PROVIDER: PRJNA170218 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR30595366_1.fastq.gz	Fastqsanger.gz
	SRR519122_1.fastq.gz	Fastqsanger.gz
	SRR519122_2.fastq.gz	Fastqsanger.gz
	SRR519464_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Notechis scutatus

Project description:Notechis scutatus Transcriptome or Gene expression

| PRJNA170152 | ENA

Notechis scutatus

Project description:Notechis scutatus (Mainland Tiger Snake), rNotScu1, chromosome-level genome assembly

| PRJNA1149914 | ENA

Malimbus scutatus

Project description:Malimbus scutatus

| PRJNA960456 | ENA

Rumex scutatus

Project description:Rumex scutatus

| PRJNA1138198 | ENA

Augastes scutatus

Project description:Augastes scutatus

| PRJNA920159 | ENA

Pyroderus scutatus strain:NA

Project description:Pyroderus scutatus

| PRJNA968352 | ENA

Aspidelaps scutatus breed:Captive bred

Project description:Aspidelaps scutatus breed:Captive bred Transcriptome or Gene expression

| PRJNA480570 | ENA

Mainland tiger snake genome project

Project description:De novo whole genome sequencing of the mainland tiger snake, Notechis scutatus

| PRJEB27871 | ENA

Project description:Alternative scaffolds for de novo whole genome sequencing of the mainland tiger snake, Notechis scutatus.

| PRJEB29452 | ENA

Dissociation of lethal toxicity and enzymic activity of notexin from Notechis scutatus scutatus (Australian-tiger-snake) venom by modification of tyrosine residues.

Project description:Notexin from Notechis scutatus scutatus snake venom was subjected to tyrosine modification with p-nitrobenzenesulphonyl fluoride (NBSF), and four modified derivatives were separated by h.p.l.c. The results of amino acid analysis and sequence determination revealed that only Tyr-7, Tyr-70 and Tyr-77 were modified in notexin. Modification of Tyr-7 resulted in decreases in lethal toxicity and enzymic activity by 70.2% and 22.7% respectively. Conversely, modification of Tyr-77 caused a 1.8-fold increase in enzymic activity, in contrast with the loss of 52.5% of lethality. A drastic decrease in lethal toxicity was observed when both Tyr-7 and Tyr-70 were modified, whereas the enzymic activity decreased by only 35.8%. Likewise, the derivative in which Tyr-7 and Tyr-77 were modified retained 44.4% of enzymic activity, but showed a marked decrease in lethal toxicity. It is obvious that modification of tyrosine residues causes a decrease in lethal toxicity of notexin, which does not directly correlate with the change in enzymic activity. On the other hand, the antigenicity of NBS derivatives remained unchanged. The modified derivatives retained their affinity for Ca2+, indicating that the modified tyrosine residues did not participate in Ca2+ binding. These results indicate that modification of tyrosine residues can differentially influence the enzymic activity and lethal toxicity of notexin, and suggest that notexin might possess two functional sites, one being responsible for the catalytic activity and the other associated with its lethal effect.

| S-EPMC1130516 | biostudies-other

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data