Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Francisella tularensis subsp. tularensis SCHU S4

ABSTRACT: Francisella tularensis Schu4 gene expression during infection of mouse spleen

PROVIDER: PRJNA171923 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Francisella tularensis subsp. tularensis SCHU S4

Project description:Francisella tularensis tularensis Schu_S4 Genome sequencing

| PRJNA239340 | ENA

Francisella tularensis subsp. tularensis SCHU S4

Project description:Genome Sequencing of 3 Select Agent-Exempt Strains of Francisella tularensis subsp. tularensis SCHU S4

| PRJNA341509 | ENA

Francisella tularensis subsp. tularensis SCHU S4

Project description:virulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophages

| PRJNA113073 | ENA

Francisella tularensis subsp. tularensis strain:SCHU-P0, SCHU-P5, SCHU-P9

Project description:Francisella tularensis subsp. tularensis multi-isolate project

| PRJDA51189 | ENA

Francisella tularensis subsp. tularensis str. SCHU S4 substr. SL

Project description:Francisella tularensis subsp. tularensis str. SCHU S4 substr. SL Genome sequencing and assembly

| PRJNA217351 | ENA

Francisella tularensis subsp. tularensis str. SCHU S4 substr. FSC237

Project description:Francisella tularensis subsp. tularensis str. SCHU S4 substr. FSC237 Genome sequencing and assembly

| PRJNA217352 | ENA

In vivo screen of Francisella tularensis subsp. novicida mutants in sequence defined transposon library

Project description:We used an inhalation mouse model of infection to query a collection of 2149 mutants in a Francisella tularensis subsp. novicida background for genes required for growth, survival and systemic dissemination. A microarray-based genome-wide negative selection screen (Microarray tracking of transposon mutants = MATT) allowed us to monitor the behavior of transposon insertions in 1371 unique genes. Interestingly most of these genes persisted in lung and colonized liver and spleen. We found 44 (35%) genes negatively selected in lung and 81 (65%) genes negatively selected in liver and/or spleen. If negative selection in lung occurred, the attenuated mutants in general persisted at 24h after infection, disseminated to liver and/or spleen and appeared to be lost in lung after 48 to 72h of infection. These genes with a strong phenotype in lung but also potential for dissemination might be attractive vaccine or drug candidates. Keywords: Genome-Wide Negative Selection Screen

2008-12-31 | GSE11297 | GEO

The role and mechanism of erythrocyte invasion by Francisella tularensis

Project description:Francisella tularensis, is an extremely virulent bacterium that can be transmitted naturally by blood sucking arthropods. During mammalian infection, F. tularensis infects numerous types of host cells, including erythrocytes. As erythrocytes do not undergo phagocytosis or endocytosis, it remains unknown how F. tularensis invades these cells. Furthermore, the consequence of inhabiting the intracellular space of red blood cells has not been determined. Here, we provide evidence indicating that residing within an erythrocyte enhances the ability of F. tularensis to colonize ticks following a blood meal.

2017-05-24 | GSE93233 | GEO

Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-10492

Project description:Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-10492 Genome sequencing and assembly

| PRJNA217349 | ENA

Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-643

Project description:Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-643 Genome sequencing and assembly

| PRJNA217350 | ENA