Saccharomyces cerevisiae
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA187512 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Tangeretin is a member of the polymethoxyflavones in citrus peel, which have been of interest due to their anti-atherogenic, anti-inflammatory, and anti-carcinogenic properties. However, their detailed target pathways have not been fully discovered. We applied the notion of chemical-genetic and genetic interactions in budding yeast, screening the putative targeting pathways of tangeretin, and we found that sgs1△ yeast was sensitive to tangeretin treatment. Therefore, we applied this microarray test to investigate the potential pathways influenced by tangeretin in sgs1. The gene expression profiles of WT and sgs1△ mutated yeast under tangeretin treatment were compared. The gene expression profiles of S. cerevisiae WT and sgs1△ strains under 30 μM tangeretin treatment for 4 hours were compared. Triplicated tests were made for each sample (tangeretin-treated WT, control-treated WT, tangeretin-treated sgs1△, control-treated sgs1△).
2013-01-29 | E-GEOD-43799 | biostudies-arrayexpress
Project description:Tangeretin is a member of the polymethoxyflavones in citrus peel, which have been of interest due to their anti-atherogenic, anti-inflammatory, and anti-carcinogenic properties. However, their detailed target pathways have not been fully discovered. We applied the notion of chemical-genetic and genetic interactions in budding yeast, screening the putative targeting pathways of tangeretin, and we found that sgs1△ yeast was sensitive to tangeretin treatment. Therefore, we applied this microarray test to investigate the potential pathways influenced by tangeretin in sgs1. The gene expression profiles of WT and sgs1△ mutated yeast under tangeretin treatment were compared.
2013-01-29 | GSE43799 | GEO
Project description:Sgs1-deficient Saccharomyces cerevisiae Genome sequencing
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Project description:Wild type and sgs1 null yeast were grown under DNA damaging (with MMS) conditions or without treatment to log phase and their transcriptional profiles compared. The human aging diseases Werner and Bloom syndromes are a result of mutation of the WRN and BLM genes, respectively. The SGS1 gene of Saccharomyces cerevisiae is homologous to the human WRN and BLM genes of the RecQ DNA helicase family. Deletion of SGS1 results in accelerated yeast aging and a reduction in life span as well as cell cycle arrest. We demonstrate that SGS1 deletion, DNA damage, and stress show similar transcriptional responses in yeast. Our comparative analysis of the genome-wide expression response of SGS1 deletion, stress and DNA damage indicates parallel transcriptional responses to cellular insult and aging in yeast.
2007-07-07 | E-GEOD-423 | biostudies-arrayexpress
Project description:Gene expression profiles of WT and ime4-/- mutant yeast cells, under vegetative and meiosis-inducing conditions
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Project description:Expression data from yeast wild type (WT) and sod1Δ strains after treatment with hydrogen peroxide (H2O2)
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Project description:Expression data from Saccharomyces cerevisiae WT, WT(hsf1), hac1∆ and hac1∆(hsf1)
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Project description:Wild type and sgs1 null yeast were grown under DNA damaging (with MMS) conditions or without treatment to log phase and their transcriptional profiles compared . The human aging diseases Werner and Bloom syndromes are a result of mutation of the WRN and BLM genes, respectively. The SGS1 gene of Saccharomyces cerevisiae is homologous to the human WRN and BLM genes of the RecQ DNA helicase family. Deletion of SGS1 results in accelerated yeast aging and a reduction in life span as well as cell cycle arrest. We demonstrate that SGS1 deletion, DNA damage, and stress show similar transcriptional responses in yeast. Our comparative analysis of the genome-wide expression response of SGS1 deletion, stress and DNA damage indicates parallel transcriptional responses to cellular insult and aging in yeast. Keywords: other
2003-06-03 | GSE423 | GEO