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Differential programming of B cells in Aicda-/- mice

ABSTRACT: Differential programming of B cells in Aicda-/- mice

PROVIDER: PRJNA207339 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR886402.fastq.gz	Fastqsanger.gz
	SRR886403.fastq.gz	Fastqsanger.gz
	SRR886404.fastq.gz	Fastqsanger.gz
	SRR886405.fastq.gz	Fastqsanger.gz
	SRR886406.fastq.gz	Fastqsanger.gz

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Differential programming of B cells in Aicda-/- mice [MethylCap-Seq]

Project description:We determined CpG methylation load from GC B cells obtained from both Aicda-/- and Aicda+/+ mice. Examination of methylation load of Aicda-/- and Acida+/+ GC B cells.

2013-06-07 | E-GEOD-47704 | biostudies-arrayexpress

Differential programming of B cells in Aicda-/- mice [RNA-Seq]

Project description:We sequenced mRNA from naive, in vitro activated, and GC B cells obtained from both Aicda-/- and Aicda+/+ mice. Examination of mRNA levels in naive, in vitro activated, and GC B cells.

2013-06-07 | E-GEOD-47703 | biostudies-arrayexpress

Differential programming of B cells in Aicda-/- mice [MethylCap-Seq]

Project description:We determined CpG methylation load from GC B cells obtained from both Aicda-/- and Aicda+/+ mice.

2013-06-07 | GSE47704 | GEO

Differential programming of B cells in Aicda-/- mice [RNA-Seq]

Project description:We sequenced mRNA from naive, in vitro activated, and GC B cells obtained from both Aicda-/- and Aicda+/+ mice.

2013-06-07 | GSE47703 | GEO

Differential programming of intestinal tissues in SETD2-/- mice

Project description:Differential programming of intestinal tissues in SETD2-/- mice

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Differential programming of B cells in Aicda-/- mice

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-06-07 | E-GEOD-47705 | biostudies-arrayexpress

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Project description:Differential programming of B cells in Aicda-/- mice [RNA-Seq]

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Mus musculus

Project description:Differential programming of B cells in Aicda-/- mice [MethylCap-Seq]

| PRJNA207340 | ENA

Differential programming of B cells in Aicda-/- mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-06-07 | GSE47705 | GEO

AICDA-induced epigenetic plasticity accelerates germinal center-derived lymphomagenesis

Project description:Epigenetic heterogeneity is emerging as a significant phenotypic feature of tumors. In diffuse large B-cell lymphomas (DLBCLs), increased cytosine methylation heterogeneity is associated with poor clinical outcome, yet the biological mechanisms driving epigenetic heterogeneity remain unclear. Activation-induced cytidine deaminase (AICDA), an enzyme that deaminates and facilitates demethylation of DNA methyl-cytosines in germinal center (GC) B-cells, is required for DLBCL pathogenesis and linked to inferior clinical outcomes. Here, we show that overexpression of AICDA causes more aggressive disease and worse outcome in BCL2-driven murine lymphomas. This phenotype was associated with significantly increased focal inter-tumor and intra-tumor cytosine methylation heterogeneity as compared to control lymphomas, but not with increased mutational burden. AICDA-mediated epigenetic heterogeneity was accompanied by DNA hypomethylation. Reciprocally, we observed that the focal inter-individual and intra-individual cytosine methylation heterogeneity characteristic of normal GC B-cells was lost upon depletion of AICDA. There was significant overlap of AICDA-induced methylation heterogeneity foci in GC B-cells and murine lymphomas. These observations are relevant to human patients, since DLBCLs with high AICDA expression likewise manifest extensive increases in focal inter-patient and intra-patient heterogeneity as compared to DLBCLs with low AICDA expression. Affected regions significantly overlapped with those found in murine AICDA-overexpressing lymphomas. Our results identify AICDA as a novel source of epigenetic plasticity and heterogeneity in B-cell lymphomas with potential significance for other tumors that express cytosine deaminases.

2018-01-19 | GSE95013 | GEO

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