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Myotis brandtii

ABSTRACT: Brandt's bat

PROVIDER: PRJNA209097 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR611177_1.fastq.gz	Fastqsanger.gz
	SRR611177_2.fastq.gz	Fastqsanger.gz
	SRR611178_1.fastq.gz	Fastqsanger.gz
	SRR611178_2.fastq.gz	Fastqsanger.gz

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Transcriptome sequencing of Myotis brandtii

2013-06-17 | GSE42297 | GEO

Transcriptome sequencing of Myotis brandtii

Project description:Deep sequencing of mRNA from Myotis brandtii. Analysis of poly(A)+ RNA of livers, kidneys and brains from M. brandtii hibernated for 2 months, hibernated for 6 months and summer active animals. Livers, kidneys and brains from M. brandtii hibernated for 2 and 6 months, and summer active animals.

2013-06-17 | E-GEOD-42297 | biostudies-arrayexpress

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myotis bat morbillivirus

Project description:We report myotis bat morbillivirus sequence indentification from myotis riparius

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Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii.

Project description:Bats account for one-fifth of mammalian species, are the only mammals with powered flight, and are among the few animals that echolocate. The insect-eating Brandt's bat (Myotis brandtii) is the longest-lived bat species known to date (lifespan exceeds 40 years) and, at 4-8?g adult body weight, is the most extreme mammal with regard to disparity between body mass and longevity. Here we report sequencing and analysis of the Brandt's bat genome and transcriptome, which suggest adaptations consistent with echolocation and hibernation, as well as altered metabolism, reproduction and visual function. Unique sequence changes in growth hormone and insulin-like growth factor 1 receptors are also observed. The data suggest that an altered growth hormone/insulin-like growth factor 1 axis, which may be common to other long-lived bat species, together with adaptations such as hibernation and low reproductive rate, contribute to the exceptional lifespan of the Brandt's bat.

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Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells (CUT&RUN)

Project description:Bats are a major reservoir of zoonotic viruses, and there has been growing interest in characterizing bat-specific features of innate immunity and inflammation. Recent studies have revealed bat-specific adaptations affecting interferon (IFN) signaling and IFN-stimulated genes (ISGs), but we still have a limited understanding of the genetic mechanisms that have shaped the evolution of bat immunity. Here we investigated the transcriptional and epigenetic dynamics of transposable elements (TEs) during the type I IFN response in little brown bat (Myotis lucifugus) primary embryonic fibroblast cells, using RNA-seq and CUT&RUN. We found multiple bat-specific TEs that undergo both locus-specific and family-level transcriptional upregulation in response to IFN. Our transcriptome reassembly identified multiple ISGs that have acquired novel exons from bat-specific TEs, including NRLC5, SLNF5 and a previously unannotated isoform of the IFITM2 gene. We also identified examples of TE-derived regulatory elements, but did not find strong evidence supporting genome-wide epigenetic activation of TEs in response to IFN. Collectively, our study uncovers numerous TE-derived transcripts, proteins, and alternative isoforms that are induced by IFN in Myotis lucifugus cells, highlighting potential candidate loci that contribute to bat-specific immune function.

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Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells (RNA-Seq)

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