Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Caenorhabditis elegans

ABSTRACT: Deep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of 1-methylnicotinamide (MNA) and nicotinic acid (NA)

PROVIDER: PRJNA214676 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR949218.fastq.gz	Fastqsanger.gz
	SRR949219.fastq.gz	Fastqsanger.gz
	SRR949220.fastq.gz	Fastqsanger.gz
	SRR949221.fastq.gz	Fastqsanger.gz
	SRR949222.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Deep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of 1-methylnicotinamide (MNA) and nicotinic acid (NA)

Project description:Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan of different species. Contrasting recent observations, we here find that overexpression of sir-2.1, the orthologue of mammalian SirT1, does extend C. elegans lifespan. Sirtuins are known to convert NAD+ into nicotinamide (NAM). We here find that NAM and its metabolite, 1-methylnicotinamide (MNA), extend C. elegans lifespan, also in the absence of sir-2.1. Consistently, impairment of sir-2.1 prevents extension of lifespan by nicotinic acid (NA), a NAD+ precursor. Taken together, sirtuins extend lifespan by promoting formation of MNA to generate a phase I - mediated ROS signal, providing an unexpected mechanistic role for sirtuins beyond histone deacetylation. 9 samples: 3 mRNA profiles of C.elegans 48h after L4 exposed to nicotinic acid; 3 mRNA profiles of C.elegans 48h after L4 exposed to 1-MNA; 3 mRNA profiles of C.elegans 48h after L4 as controls (H20)

2013-08-09 | E-GEOD-49662 | biostudies-arrayexpress

Deep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of 1-methylnicotinamide (MNA) and nicotinic acid (NA)

2013-08-09 | GSE49662 | GEO

Caenorhabditis elegans

Project description:Deep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of arsenite

| PRJNA198476 | ENA

Caenorhabditis elegans

Project description:Deep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of rotenone at 4 different time points

| PRJNA197200 | ENA

Caenorhabditis elegans

Project description:Caenorhabditis elegans

| PRJNA265871 | ENA

Caenorhabditis elegans

Project description:Caenorhabditis elegans Variation

| PRJNA76497 | ENA

Caenorhabditis elegans

Project description:Caenorhabditis elegans sequencing

| PRJNA548154 | ENA

Caenorhabditis elegans

Project description:Caenorhabditis elegans Epigenomics

| PRJNA649048 | ENA

Caenorhabditis elegans founder strain mitochondrial UPR proteomics

Project description:This dataset consists of 20 proteomics raw files of two Caenorhabditis elegans strains: N2 and CB4856 under two conditions.

2021-12-28 | MSV000088622 | MassIVE

Caenorhabditis elegans

Project description:Deep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence of 2-deoxy-D-glucose (DOG) at 4 different time points

| PRJNA198785 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data