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Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress [set1]

ABSTRACT: Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress [set1]

OTHER RELATED OMICS DATASETS IN: GSE74820

PROVIDER: PRJNA255780 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1521750.fastq.gz	Fastqsanger.gz
	SRR1521760.fastq.gz	Fastqsanger.gz
	SRR1521770.fastq.gz	Fastqsanger.gz
	SRR1521751.fastq.gz	Fastqsanger.gz
	SRR1521761.fastq.gz	Fastqsanger.gz

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Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress

Project description:Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress

| PRJNA301598 | ENA

Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress [set1]

2016-03-09 | GSE59632 | GEO

Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress [set2]

Project description:Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress [set2]

| PRJNA301602 | ENA

Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress [set1]

Project description:We use RNA-Seq to investigate gene expression differences in response to saltwater exposure by the larval stages of the obligate freshwater mosquito Anopheles coluzzii (formerly An. gambiae "M" form), and the euryhaline An. merus. After rearing in freshwater, both young and old larval instars of each species were briefly (6 h) exposed to either saltwater (SW) or freshwater (FW) conditions to test the impact of salinity on mRNA levels.

2016-03-09 | E-GEOD-59632 | biostudies-arrayexpress

Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress.

Project description:Evolution of osmoregulatory systems is a key factor in the transition of species between fresh- and saltwater habitats. Anopheles coluzzii and Anopheles merus are stenohaline and euryhaline malaria vector mosquitoes belonging to a larger group of sibling species, the Anopheles gambiae complex, which radiated in Africa within the last 2 million years. Comparative ecological genomics of these vector species can provide insight into the mechanisms that permitted the rapid radiation of this species complex into habitats of contrasting salinity. Here, we use RNA-Seq to investigate gene expression differences between An. coluzzii and An. merus after briefly exposing both young and old larval instars of each species to either saltwater (SW) or freshwater (FW). Our study aims to identify candidate genes and pathways responsible for the greater SW tolerance of An. merus. Our results are congruent with the ability of gene induction to mediate salinity tolerance, with both species showing increasing amounts of differential gene expression between SW and FW as salt concentrations increase. Besides ion transporters such as AgAE2 that may serve as effectors for osmoregulation, we also find mitogen-activated protein kinases that may serve in a phosphorylation signalling pathway responding to salinity, and report potential cross-talk between the mosquito immune response and osmoregulation. This study provides a key step towards applying the growing molecular knowledge of these malaria vectors to improve understanding of their ecological tolerances and habitat occupancy.

| S-EPMC4877251 | biostudies-literature

Insights into the epigenomic landscape of the human malaria vector Anopheles gambiae

Project description:We characterize the epigenome of the human malaria vector Anopheles gambiae in midgut cells by mapping the distribution and levels of two post-translational histone modifications, H3K27ac and H3K27me3. These histone profiles were then correlated with levels of gene expression obtained by RNA-seq.

2014-09-04 | GSE59773 | GEO

Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-03-09 | GSE74820 | GEO

Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress [set2]

Project description:We use RNA-Seq to explore the reaction norm of gene expression of larval Anopheles coluzzii and An. merus to a gradient of salinity.

2016-03-09 | GSE74819 | GEO

Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress [set2]

Project description:We use RNA-Seq to explore the reaction norm of gene expression of larval Anopheles coluzzii and An. merus to a gradient of salinity. After rearing in freshwater, separate pools of 18 h post-hatch larval instars of An. merus and An. coluzzii were briefly (6 h) exposed to one of six water salinities: 0%, 10%, 20%, 30%, 40%, or 50% the salinity of seawater. The last sample (G-50-RC) was split across 5 lanes for sequencing, resulting in total 10 fastq files associated with subparts G-50-RCa, G-50-RCb, G-50-RCc, G-50-RCd, G-50-RCe.

2016-03-09 | E-GEOD-74819 | biostudies-arrayexpress

Cla4 catalyzed Set1 phosphorylation

Project description:H3K4me3 is catalyzed by the Set1/MLL family of methyltransferases, whose function in catalyzing H3K4me3 is unique. Impaired function of Set1/MLL family members can lead to many abnormalities, such as bone and nerve defects, leukemia, and even death. Although the Set1 family plays an important regulatory role in various biological processes, it is still unclear how the Set1 protein itself is regulated and how protein levels are maintained. Due to the numerous homologues, complex composition, and high molecular weight of Set1 in higher organisms, especially humans, related research is greatly limited. In brewing yeast, Set1 is the only methyltransferase that catalyzes H3K4me3 and is highly conserved between species. Therefore, yeast is an ideal model for studying the functions and mechanisms of the Set1 family. In addition, Set1 protein plays an important role in regulating gene transcription, promoting telomere silencing, and maintaining cell lifespan. The Set1 family also plays an important regulatory role in the occurrence and development of various cancers.

2023-10-24 | PXD042010 | Pride

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