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Drosophila melanogaster

ABSTRACT: A Novel Role of Polycomb in Positive Transcription Regulation by Modulating H4K20me1

PROVIDER: PRJNA257070 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1532700.fastq.gz	Fastqsanger.gz
	SRR1532701.fastq.gz	Fastqsanger.gz
	SRR1532702.fastq.gz	Fastqsanger.gz
	SRR1532703.fastq.gz	Fastqsanger.gz

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A Novel Role of Polycomb in Positive Transcription Regulation by Modulating H4K20me1

Project description:Polycomb group (PcG) proteins were originally shown to play central roles in maintaining heritable gene suppression during the normal development of higher eukaryotes. However, recent studies in Drosophila and mammals imply a potential positive role of PcG proteins in gene transcription with unknown mechanism. Here, for the first time we report Pc-mediated, E(z)/H3K27me3-dependent positive transcription regulation of Ci and Sens, two key transcription factors involved in body plan during normal development. Further mechanistic studies showed that Pc regulates Sens expression by regulating H4K20me1 at Sens locus. More importantly, this mechanism applies to other genes involved in the developmental process. In summary, we report a novel and general transcription regulation mechanism, that is, Pc-mediated, E(z)/H3K27me3-dependent positive transcription regulation by modulating H4K20me1 during development.

2016-04-12 | GSE59924 | GEO

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Project description:Polycomb Repressive Complex 1 regulates transcription of active genes [NTseq]

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Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation [RNA-Seq]

Project description:Mono-methylation of Lysine 20 of histone H4 (H4K20me1) is catalyzed by Set8 and thought to play important roles in many aspects of genome function that are mediated by H4K20me-binding proteins. We interrogated this model in a developing animal by comparing in parallel the transcriptomes of Set8null, H4K20R/A, and l(3)mbt mutant Drosophila melanogaster. We found that the gene expression profiles of H4K20A and H4K20R larvae are markedly different than Set8null larvae despite similar reductions in H4K20me1. Set8null mutant cells have a severely disrupted transcriptome and fail to proliferate in vivo, but these phenotypes are not recapitulated by mutation of H4K20 indicating that the developmental defects of Set8null animals are largely due to H4K20me1-independent effects on gene expression. Further, the H4K20me1 binding protein L(3)mbt is recruited to the transcription start sites of most genes independently of H4K20me even though genes bound by L(3)mbt have high levels of H4K20me1. Moreover, both Set8 and L(3)mbt bind to purified H4K20R nucleosomes in vitro. We conclude that gene expression changes in Set8null and H4K20 mutants cannot be explained by loss of H4K20me1 or L(3)mbt binding to chromatin, and therefore that H4K20me1 does not play a large role in gene expression.

2024-06-07 | GSE268821 | GEO

Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation [H4K20me1_CUT&RUN]

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Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation [GFP-L3mbt_CUT&RUN]

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