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Hymenolepis diminuta

ABSTRACT: Hymenolepis diminuta overview

PROVIDER: PRJNA261759 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR9275651_1.fastq.gz	Fastqsanger.gz
	SRR9275651_2.fastq.gz	Fastqsanger.gz
	SRR9275652_1.fastq.gz	Fastqsanger.gz
	SRR9275652_2.fastq.gz	Fastqsanger.gz

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Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages

Project description:Mouse infection with the tapeworm Hymenolepis diminuta leads to a less severe DNBS-colitis. Increased Th2 and regulatory cytokine production in the spleen is a hallmark of Hymenolepis diminuta infection, therefore we hypothesized that given this microenvironment, splenic adaptive cells acquire an anti-inflammatory phenotype. We tested the ability of putative splenic regulatory B cells generated by Hymenolepis diminuta infection to down-regulate intestinal inflammation. We found that unlike splenic B cells from uninfected mice, splenic B cells from Hymenolepis diminuta -infected animals ameliorated chemically-induced colitis.

2015-02-20 | GSE61460 | GEO

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Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages

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Comparative genomics of Hymenolepis diminuta strains

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Hymenolepis diminuta Genome sequencing

Project description:Genomic assembly of cestode Hymenolepis diminuta, as part of the 50 Helminth Genomes Initiative sequencing of the parasitic worms that have the greatest impact on human, agricultural and veterinary disease and cause significant global health issues particularly in the developing world, or those used as model organisms.

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Transcriptome sequencing of Hymenolepis microstoma a classic laboratory model in cestodology

Project description:Hymenolepis spp. (H. diminuta, H. nana and H. microstoma) are rodent-hosted tapeworms (Platyhelminthes: Cestoda) that have been used as laboratory and teaching models since the 1950s, and consequently much of our understanding of the basic physiology, biochemistry and anatomy of tapeworms in general stems from research using these species. As representatives of the order Cyclophyllidea, they are closely related to species with significant medical and economic importance such as Taenia and Echinococcus spp., but unlike these may be maintained in vivo using only laboratory mice and flour beetles (n.b. Echinoccous spp. are hosted by foxes and Taenia spp. are hosted by pigs or cows). This effort brings a classical laboratory model into the genomic age, allowing researchers in silico access to its genome and expressed gene transcripts and thereby greatly expediting research directed at understanding the genetic basis of tapeworm biology.

2013-01-28 | E-ERAD-56 | biostudies-arrayexpress

Cestode Antigens Block LPS-induced Inflammatory Mediators and Condition Macrophages to Educate Anti-colitic T Cells

Project description:We tested the ability of rat worm Hymenolepis diminuta parasite crude antigens (HdAg) to induce a regulatory-associated program in bone-marrow derived macrophages (BMMs). Also, we compared gene expression profile of BMMs exposed to HdAg with those exposed to IL-4 which elicits a well-known alternative program.

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