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Hymenolepis diminuta

ABSTRACT: Hymenolepis diminuta Transcriptome or Gene expression

PROVIDER: PRJNA546290 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9275651_1.fastq.gz	Fastqsanger.gz
	SRR9275651_2.fastq.gz	Fastqsanger.gz
	SRR9275652_1.fastq.gz	Fastqsanger.gz
	SRR9275652_2.fastq.gz	Fastqsanger.gz
	SRR9275653_1.fastq.gz	Fastqsanger.gz

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Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages

Project description:Mouse infection with the tapeworm Hymenolepis diminuta leads to a less severe DNBS-colitis. Increased Th2 and regulatory cytokine production in the spleen is a hallmark of Hymenolepis diminuta infection, therefore we hypothesized that given this microenvironment, splenic adaptive cells acquire an anti-inflammatory phenotype. We tested the ability of putative splenic regulatory B cells generated by Hymenolepis diminuta infection to down-regulate intestinal inflammation. We found that unlike splenic B cells from uninfected mice, splenic B cells from Hymenolepis diminuta -infected animals ameliorated chemically-induced colitis.

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Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages

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Cestode Antigens Block LPS-induced Inflammatory Mediators and Condition Macrophages to Educate Anti-colitic T Cells

Project description:We tested the ability of rat worm Hymenolepis diminuta parasite crude antigens (HdAg) to induce a regulatory-associated program in bone-marrow derived macrophages (BMMs). Also, we compared gene expression profile of BMMs exposed to HdAg with those exposed to IL-4 which elicits a well-known alternative program.

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