Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-28534

ABSTRACT: Sequencing of Francisella tularensis susp. tulatrensis SCHU S4 strain used in a Natural History and Model Characterization Study of an inhalational tularemia model in Cynomolgus macaques.

PROVIDER: PRJNA270247 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR1714340_consensus.fastq.gz	Fastqsanger.gz
	SRR1714341_consensus.fastq.gz	Fastqsanger.gz
	SRR1714339_1.fastq.gz	Fastqsanger.gz
	SRR1714339_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 5

Similar Datasets

Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-10492

Project description:Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-10492 Genome sequencing and assembly

| PRJNA217349 | ENA

Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-643

Project description:Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-643 Genome sequencing and assembly

| PRJNA217350 | ENA

Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-28534

Project description:Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-28534 Genome sequencing and assembly

| PRJNA217348 | ENA

Francisella tularensis subsp. tularensis SCHU S4

Project description:Genome Sequencing of 3 Select Agent-Exempt Strains of Francisella tularensis subsp. tularensis SCHU S4

| PRJNA341509 | ENA

Francisella tularensis subsp. tularensis str. SCHU S4 substr. SL

Project description:Francisella tularensis subsp. tularensis str. SCHU S4 substr. SL Genome sequencing and assembly

| PRJNA217351 | ENA

Francisella tularensis subsp. tularensis str. SCHU S4 substr. FSC237

Project description:Francisella tularensis subsp. tularensis str. SCHU S4 substr. FSC237 Genome sequencing and assembly

| PRJNA217352 | ENA

Francisella tularensis subsp. tularensis SCHU S4

Project description:Aquatic bacterium that cause tularemia

| PRJNA9 | ENA

Francisella tularensis subsp. tularensis SCHU S4

Project description:Francisella tularensis tularensis Schu_S4 Genome sequencing

| PRJNA239340 | ENA

Arginine catabolism and polyamine biosynthesis pathway disparities within Francisella tularensis subpopulations

Project description:Francisella tularensis is a highly infectious zoonotic pathogen with as few as 10 organisms causing tularemia, a disease that is fatal if untreated. Although F. tularensis subspecies tularensis (type A) and subspecies holarctica (type B) share over 99.5% average nucleotide identity, notable differences exist in genomic organization and pathogenicity. The type A clade has been further divided into subtypes A.I and A.II, with A.I strains being recognized as some of the most virulent bacterial pathogens known. In this study, we report on major disparities that exist between the F. tularensis subpopulations in arginine catabolism and subsequent polyamine biosynthesis. The genes involved in these pathways include the speDEA and aguAB operons, along with metK. In the hypervirulent F. tularensis A.I clade, such as the A.I prototype strain SCHU S4, these genes were found to be intact and highly transcribed. In contrast, both subtype A.II and type B strains have a truncated speA gene, while the type B clade also has a disrupted aguA and truncated aguB. Ablation of the chromosomal speE gene that encodes a spermidine synthase reduced subtype A.I SCHU S4 growth rate, whereas the growth rate of type B LVS was enhanced. These results demonstrate that spermine synthase SpeE promotes faster replication in the F. tularensis A.I clade, whereas type B strains do not rely on this enzyme for fitness. Our ongoing studies on metabolism should provide a better understanding of the factors that contribute to F. tularensis pathogenicity.

2022-07-13 | GSE202948 | GEO

Francisella tularensis subsp. tularensis str. SCHU S4 substr. FTS-634/635

Project description:Francisella tularensis subsp. tularensis str. SCHU S4 substr. FTS-634/635 Genome sequencing and assembly

| PRJNA217353 | ENA