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Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-643

ABSTRACT: Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-643 Genome sequencing and assembly

PROVIDER: PRJNA217350 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR1019709_1.fastq.gz	Fastqsanger.gz
	SRR1019709_2.fastq.gz	Fastqsanger.gz
	SRR999322_1.fastq.gz	Fastqsanger.gz
	SRR999322_2.fastq.gz	Fastqsanger.gz

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Francisella tularensis subsp. tularensis SCHU S4

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Transcription profiling of human monocytes infected with Francisella tularensis

Project description:Differential expression in human peripheral blood monocytes between F. novicida-infected and uninfected, and between Francisella tularensis tularensis isolate Schu S4 and uninfected. The goal was to examine genomewide transcriptional reponses to these two strains, and identify differentially-regulated genes that may help explain the virulence of Schu S4. Experiment Overall Design: Human monocytes were infected with the Schu S4 isolate of Francisella tularensis tularensis (n=4), with F. tularensis subspecies novicida isolate U112 (n=4) or were left uninfected (n=6). Gene expression values were calculated using the gcrma package in R and BioConductor, and limma to identify differentially expressed genes. Submitted here are expression values calculated using R 2.7.1 and BioConductor 2.2 (FreeBSD/amd64) but the original were done using R 2.6.1 and BioConductor 2.1 (FreeBSD/amd64). Twelve other chips were pooled with these 14 for preprocessing.

2008-10-25 | E-GEOD-12108 | biostudies-arrayexpress

Francisella tularensis subsp. tularensis str. SCHU S4 substr. NR-28534

Project description:Sequencing of Francisella tularensis susp. tulatrensis SCHU S4 strain used in a Natural History and Model Characterization Study of an inhalational tularemia model in Cynomolgus macaques.

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Arginine catabolism and polyamine biosynthesis pathway disparities within Francisella tularensis subpopulations

Project description:Francisella tularensis is a highly infectious zoonotic pathogen with as few as 10 organisms causing tularemia, a disease that is fatal if untreated. Although F. tularensis subspecies tularensis (type A) and subspecies holarctica (type B) share over 99.5% average nucleotide identity, notable differences exist in genomic organization and pathogenicity. The type A clade has been further divided into subtypes A.I and A.II, with A.I strains being recognized as some of the most virulent bacterial pathogens known. In this study, we report on major disparities that exist between the F. tularensis subpopulations in arginine catabolism and subsequent polyamine biosynthesis. The genes involved in these pathways include the speDEA and aguAB operons, along with metK. In the hypervirulent F. tularensis A.I clade, such as the A.I prototype strain SCHU S4, these genes were found to be intact and highly transcribed. In contrast, both subtype A.II and type B strains have a truncated speA gene, while the type B clade also has a disrupted aguA and truncated aguB. Ablation of the chromosomal speE gene that encodes a spermidine synthase reduced subtype A.I SCHU S4 growth rate, whereas the growth rate of type B LVS was enhanced. These results demonstrate that spermine synthase SpeE promotes faster replication in the F. tularensis A.I clade, whereas type B strains do not rely on this enzyme for fitness. Our ongoing studies on metabolism should provide a better understanding of the factors that contribute to F. tularensis pathogenicity.

2022-07-13 | GSE202948 | GEO

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