Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: Trim33 binds and silences a class of young endogenous retroviruses in the mouse testis

PROVIDER: PRJNA283211 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR2011450.fastq.gz	Fastqsanger.gz
	SRR2011451.fastq.gz	Fastqsanger.gz
	SRR2011452.fastq.gz	Fastqsanger.gz
	SRR2011444.fastq.gz	Fastqsanger.gz
	SRR2011445.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Mus musculus

Project description:TRIM28 silences endogenous retroviruses in neural progenitor cells

| PRJNA196678 | ENA

Morc3 silences endogenous retroviruses in mouse embryonic stem cells

Project description:Morc3 silences endogenous retroviruses in mouse embryonic stem cells

| PRJNA727542 | ENA

Morc3 silences endogenous retroviruses in mouse embryonic stem cells [Morc3_mESCs_RNAseq]

Project description:Morc3 silences endogenous retroviruses in mouse embryonic stem cells [Morc3_mESCs_RNAseq]

| PRJNA727549 | ENA

Trim33 binds and silences a class of young endogenous retroviruses in the mouse testis

Project description:Transposable elements (TEs) have been active in the mammalian genome for hundreds of millions of years and each TE has had a distinct period of transpositional activity, followed by inactivation. Mice carrying reporter transgenes can be used to model transcriptional silencing at TEs. A mutagenesis screen for modifiers of epigenetic gene silencing produced a line with a null mutation in Trim33. Heterozygous mutants displayed increased expression of the reporter transgene. ChIP-seq of Trim33 in testis revealed 9,109 peaks, mostly at promoters, across the mouse genome. Trim33 was enriched at many RLTR10B elements that are among the youngest retrotransposons in the mouse genome. RNA-seq revealed that testis of mice haploinsufficient for Trim33 had altered expression of a small group of genes. The gene with the most significant increase, Nmnat3, was found to be transcribed from an upstream RLTR10B element. We show that Trim33 is involved in repressing RLTR10B elements in mouse testis. Examination of Trim33 binding using ChIP sequencing and the result of Trim33 haploinsufficiency using RNA sequencing, in mouse testis

2015-11-06 | E-GEOD-68617 | biostudies-arrayexpress

Morc3 silences endogenous retroviruses in mouse embryonic stem cells [ATAC-seq]

Project description:Morc3 silences endogenous retroviruses in mouse embryonic stem cells [ATAC-seq]

| PRJNA727552 | ENA

Morc3 silences endogenous retroviruses in mouse embryonic stem cells [Morc3 ChIP-seq]

Project description:Morc3 silences endogenous retroviruses in mouse embryonic stem cells [Morc3 ChIP-seq]

| PRJNA727553 | ENA

Morc3 silences endogenous retroviruses in mouse embryonic stem cells [RNA-seq CRISPR]

Project description:Morc3 silences endogenous retroviruses in mouse embryonic stem cells [RNA-seq CRISPR]

| PRJNA727551 | ENA

Morc3 silences endogenous retroviruses in mouse embryonic stem cells [H3K9me3 ChIP-seq]

Project description:Morc3 silences endogenous retroviruses in mouse embryonic stem cells [H3K9me3 ChIP-seq]