Project description:Tumors cause the induction or repression of many genes associated with inflammation. To investigate the up and down regulation of genes associated with immune stimulation or immune tolerance RNA was isolated from dendritic cells from normal or tumor bearing prostate for microarray analysis. Using the TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model and a fold change comparison system we identified genes that are associated with immune tolerance to be up-regulated and genes associated with immunity to be down regulated in tumor associated dendritic cells. Keywords: Comparative gene expression, prostate cancer, dendritic cells Prostatic dendritic cells were isolated from 4 normal and 6 tumor bearing mice for comparison of gene expression.

2011-01-20 | E-GEOD-26719 | biostudies-arrayexpress

Impaired histone inheritance promotes tumor progression

Project description:Impaired histone inheritance promotes tumor progression

| PRJNA830520 | ENA

Ikaros tumor suppression and epigenetic regulation [gene expression]

Project description:Ikaros tumor suppression and epigenetic regulation [gene expression]

| PRJNA521762 | ENA

Transcriptome analysis of tumor and normal brain endothelial cells

Project description:Transcriptome analysis of tumor and normal brain endothelial cells

| PRJNA819472 | ENA

Gene expression profile of Dclk1+ murine normal intestinal and tumor cells

Project description:Accumulating evidence has shown the existence of tumor stem cells, and many researchers and clinicians are focusing on the therapeutic potential of targeting tumor stem cells. Previously, we reported that doublecortin like kinase 1 (Dclk1) marks tumor stem cells but not normal stem cells in ApcMin/+ mouse intestine, and that selective ablation of Dclk1+ cells results in collapse of the intestinal tumors without any apparent damages in the normal mucosa. Here, we sought to clarify gene expresion profile of Dclk1+ cells by microarray analyses in mouse normal intestinal epithelium and ApcMin/+ mouse intestinal tumors. Microarray analyses demonstrated that genes related to microtubules and actin cytoskeleton (e.g., Rac2) were highly expressed in Dclk1+ normal intestinal and tumor cells. We found the expression of Src family kinases (i.e., Hck, Lyn, Csk, and Ptpn6) in Dclk1+ normal intestinal and tumor cells.

2017-06-05 | GSE99387 | GEO

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